Amanda E MacKenzie
Overview
Explore the profile of Amanda E MacKenzie including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
414
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0
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Recent Articles
1.
Lin L, Quon T, Engberg S, MacKenzie A, Tobin A, Milligan G
ACS Pharmacol Transl Sci
. 2021 Dec;
4(6):1835-1848.
PMID: 34927014
Although prevalent, nonalcoholic fatty liver disease is not currently treated effectively with medicines. Initially, using wild-type and genome-edited clones of the human hepatocyte cell line HepG2, we show that activation...
2.
Boleij A, Fathi P, Dalton W, Park B, Wu X, Huso D, et al.
Commun Biol
. 2021 May;
4(1):585.
PMID: 33990686
G protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated with inflammatory bowel diseases (IBD), suggesting a role in...
3.
Marti-Solano M, Crilly S, Malinverni D, Munk C, Harris M, Pearce A, et al.
Nature
. 2020 Nov;
588(7838):E24.
PMID: 33244189
No abstract available.
4.
Marti-Solano M, Crilly S, Malinverni D, Munk C, Harris M, Pearce A, et al.
Nature
. 2020 Nov;
587(7835):650-656.
PMID: 33149304
G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence or expression of...
5.
MacKenzie A, Quon T, Lin L, Hauser A, Jenkins L, Inoue A, et al.
FASEB J
. 2019 Jan;
33(4):5005-5017.
PMID: 30601679
Despite recent advances in structural definition of GPCR-G protein complexes, the basis of receptor selectivity between G proteins remains unclear. The Gα and Gα subtypes together form the least studied...
6.
Binti Mohd Amir N, MacKenzie A, Jenkins L, Boustani K, Hillier M, Tsuchiya T, et al.
J Immunol
. 2018 Jun;
201(2):714-724.
PMID: 29875152
The chemokine CXCL17 is associated with the innate response in mucosal tissues but is poorly characterized. Similarly, the G protein-coupled receptor GPR35, expressed by monocytes and mast cells, has been...
7.
McCallum J, MacKenzie A, Divorty N, Clarke C, Delles C, Milligan G, et al.
J Vasc Res
. 2016 Apr;
52(6):383-95.
PMID: 27064272
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent...
8.
Sergeev E, Hansen A, Pandey S, MacKenzie A, Hudson B, Ulven T, et al.
J Biol Chem
. 2015 Nov;
291(1):303-17.
PMID: 26518871
Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled free fatty acid...
9.
MacKenzie A, Milligan G
Neuropharmacology
. 2015 Aug;
113(Pt B):661-671.
PMID: 26232640
G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of...
10.
Divorty N, MacKenzie A, Nicklin S, Milligan G
Front Pharmacol
. 2015 Mar;
6:41.
PMID: 25805994
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases. However,...