Allison L Germann
Overview
Explore the profile of Allison L Germann including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
35
Citations
373
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Germann A, Pierce S, Steinbach J, Akk G
J Gen Physiol
. 2024 Nov;
157(1).
PMID: 39585302
The maximal probability of being in an active state (PA,max) is a measure of gating efficacy for a given agonist acting on a given receptor channel. In macroscopic electrophysiological recordings,...
2.
Pierce S, Germann A, Covey D, Evers A, Steinbach J, Akk G
Mol Pharmacol
. 2024 Aug;
106(5):264-277.
PMID: 39214710
The γ-aminobutyric acid type A (GABA) receptor is modulated by a number of neuroactive steroids. Sulfated steroids and 3-hydroxy steroids inhibit, while 3-hydroxy steroids typically potentiate the receptor. Here, we...
3.
Chintala S, Tateiwa H, Qian M, Xu Y, Amtashar F, Chen Z, et al.
Br J Pharmacol
. 2024 Jul;
181(21):4229-4244.
PMID: 38978389
Background And Purpose: Neurosteroids are allosteric modulators of GABA currents, acting through several functional binding sites although their affinity and specificity for each site are unknown. The goal of this...
4.
Germann A, Xu Y, Covey D, Evers A, Akk G
ACS Chem Neurosci
. 2024 Feb;
15(5):909-915.
PMID: 38386612
Activation of the GABA receptor is associated with numerous behavioral end points ranging from anxiolysis to deep anesthesia. The specific behavioral effect of a GABAergic compound is considered to correlate...
5.
Pohl F, Germann A, Mao J, Hou S, Bakare B, Kong Thoo Lin P, et al.
Sci Adv
. 2023 Nov;
9(44):eadh2584.
PMID: 37910615
The γ-aminobutyric acid-mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction, and life-span extension. Many of these phenotypes are also regulated by reactive...
6.
Pierce S, Xu S, Germann A, Steinbach J, Akk G
Biophys J
. 2023 Sep;
123(14):1954-1967.
PMID: 37752702
The properties of a potentiator are typically evaluated by measuring its ability to enhance the magnitude of the control response. Analysis of the ability of drugs to potentiate responses from...
7.
Arias H, Pierce S, Germann A, Xu S, Ortells M, Sakamoto S, et al.
Mol Pharmacol
. 2023 Jun;
104(3):115-131.
PMID: 37316350
Acrylamide-derived compounds have been previously shown to act as modulators of members of the Cys-loop transmitter-gated ion channel family, including the mammalian GABA receptor. Here we have synthesized and functionally...
8.
Pierce S, Germann A, Xu S, Menon S, Ortells M, Arias H, et al.
Biomolecules
. 2023 May;
13(4).
PMID: 37189445
The positive allosteric modulators (PAMs) of the α7 nicotinic receptor -(5-Cl-2-hydroxyphenyl)-'-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and ()-3-(furan-2-yl)--(-tolyl)-acrylamide (PAM-2) potentiate the α1β2γ2L GABA receptor through interactions with the classic anesthetic binding sites located at...
9.
Tateiwa H, Chintala S, Chen Z, Wang L, Amtashar F, Bracamontes J, et al.
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830708
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG...
10.
Arias H, Germann A, Pierce S, Sakamoto S, Ortells M, Hamachi I, et al.
Br J Pharmacol
. 2022 Sep;
179(24):5323-5337.
PMID: 36082615
Background And Purpose: Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7-PAMs) possess promnesic and procognitive properties and have potential in the treatment of cognitive and psychiatric disorders...