Allan M Gurtan
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Explore the profile of Allan M Gurtan including associated specialties, affiliations and a list of published articles.
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12
Citations
631
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Recent Articles
1.
Gurtan A, Khalid S, Koch C, Zaman Khan M, Lamarche L, Splawski I, et al.
Nat Metab
. 2024 Sep;
6(10):1913-1921.
PMID: 39327531
Growth differentiation factor 15 (GDF15) is a secreted protein that regulates food intake, body weight and stress responses in pre-clinical models. The physiological function of GDF15 in humans remains unclear....
2.
JnBaptiste C, Gurtan A, Thai K, Lu V, Bhutkar A, Su M, et al.
Genes Dev
. 2017 Jun;
31(10):1066.
PMID: 28637695
No abstract available.
3.
JnBaptiste C, Gurtan A, Thai K, Lu V, Bhutkar A, Su M, et al.
Genes Dev
. 2017 Apr;
31(7):674-687.
PMID: 28446596
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression critical for organismal viability. Changes in miRNA activity are common in cancer, but how these changes relate to subsequent alterations in transcription...
4.
Gosline S, Gurtan A, JnBaptiste C, Bosson A, Milani P, Dalin S, et al.
Cell Rep
. 2016 Jan;
14(2):310-9.
PMID: 26748710
MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated...
5.
Gurtan A, Ravi A, Rahl P, Bosson A, JnBaptiste C, Bhutkar A, et al.
Genes Dev
. 2013 May;
27(8):941-54.
PMID: 23630078
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads...
6.
Gurtan A, Sharp P
J Mol Biol
. 2013 Mar;
425(19):3582-600.
PMID: 23500488
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome. The sequence-complementary mechanism of...
7.
Ravi A, Gurtan A, Kumar M, Bhutkar A, Chin C, Lu V, et al.
Cancer Cell
. 2012 Jun;
21(6):848-55.
PMID: 22698408
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein coding genes, including many involved in basal cellular processes and organismal development. Although...
8.
Gurtan A, Lu V, Bhutkar A, Sharp P
RNA
. 2012 May;
18(6):1116-22.
PMID: 22546613
Dicer is an RNase III family endoribonuclease and haploinsufficient tumor suppressor that processes mature miRNAs from the 5' (5p) or 3' (3p) arm of hairpin precursors. In murine Dicer knockout...
9.
Kowal P, Gurtan A, Stuckert P, DAndrea A, Ellenberger T
J Biol Chem
. 2006 Nov;
282(3):2047-55.
PMID: 17082180
Fanconi anemia (FA) is a rare autosomal recessive and X-linked chromosomal instability disorder. At least eight FA proteins (FANCA, B, C, E, F, G, L, and M) form a nuclear...
10.
Machida Y, Machida Y, Chen Y, Gurtan A, Kupfer G, DAndrea A, et al.
Mol Cell
. 2006 Aug;
23(4):589-96.
PMID: 16916645
The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the monoubiquitination of the FANCD2 protein by the ubiquitin ligase...