Brian J DeBosch
Overview
Explore the profile of Brian J DeBosch including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
2016
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Recent Articles
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Sun J, DeBosch B
STAR Protoc
. 2025 Feb;
6(1):103660.
PMID: 39998953
To investigate the role of hepatocyte genes in fasting metabolism, it is essential to analyze their expression across the entire 24-h circadian cycle. Here, we present a protocol to evaluate...
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Ziolkowska E, Jansen M, Williams L, Wang S, Eultgen E, Takahashi K, et al.
Sci Transl Med
. 2025 Jan;
17(781):eadj1445.
PMID: 39813314
Children with neurodegenerative disease often have debilitating gastrointestinal symptoms. We hypothesized that this may be due at least in part to underappreciated degeneration of neurons in the enteric nervous system...
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Walker E, Javati S, Todd E, Matlam J, Lin X, Bryant M, et al.
Nat Immunol
. 2024 Nov;
25(12):2247-2258.
PMID: 39496954
Acute lower respiratory tract infection (ALRI) remains a major worldwide cause of childhood mortality, compelling innovation in prevention and treatment. Children in Papua New Guinea (PNG) experience profound morbidity from...
6.
Sun J, Zhang Y, Adams J, Higgins C, Kelly S, Zhang H, et al.
Cell Rep
. 2024 Oct;
43(10):114865.
PMID: 39412985
Organisms integrate circadian and metabolic signals to optimize substrate selection to survive starvation, yet precisely how this occurs is unclear. Here, we show that hepatocyte Period 1 (Per1) is selectively...
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Kelly S, Higgins C, Sun J, Adams J, Zhang Y, Ballentine S, et al.
PNAS Nexus
. 2024 Sep;
3(9):pgae357.
PMID: 39282008
The matrix metalloproteinase MMP14 is a ubiquitously expressed, membrane-bound, secreted endopeptidase that proteolyzes substrates to regulate development, signaling, and metabolism. However, the spatial and contextual events inciting MMP14 activation and...
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Zhang Y, Higgins C, Tica S, Adams J, Sun J, Kelly S, et al.
Cell Metab
. 2024 Aug;
36(9):2069-2085.e8.
PMID: 39116884
Urea cycle impairment and its relationship to obesity and inflammation remained elusive, partly due to the dramatic clinical presentation of classical urea cycle defects. We generated mice with hepatocyte-specific arginase...
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Qi N, Franczyk M, Yamaguchi S, Kojima D, Hayashi K, Satoh A, et al.
Am J Physiol Endocrinol Metab
. 2024 May;
327(1):E81-E88.
PMID: 38809511
Nicotinamide adenine dinucleotide (NAD) is a universal coenzyme regulating cellular energy metabolism in many cell types. Recent studies have demonstrated the close relationships between defective NAD metabolism and aging and...
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Niemi N, DeBosch B
Gastroenterology
. 2024 Feb;
166(5):936-937.
PMID: 38340873
No abstract available.