Alice Cavanaugh
Overview
Explore the profile of Alice Cavanaugh including associated specialties, affiliations and a list of published articles.
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10
Citations
380
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Recent Articles
1.
Prince T, Ackerman A, Cavanaugh A, Schreiter B, Juengst B, Andolino C, et al.
Oncotarget
. 2018 Sep;
9(66):32702-32717.
PMID: 30220976
Muscle invasive bladder cancer (MIBC) is a common malignancy and major cause of morbidity worldwide. Over the last decade mortality rates for MIBC have not decreased as compared to other...
2.
Cavanaugh A, Juengst B, Sheridan K, Danella J, Williams H
Oncotarget
. 2015 Nov;
6(37):39821-38.
PMID: 26556859
Heat shock protein 90 (HSP90) plays a critical role in the survival of cancer cells including muscle invasive bladder cancer (MIBC). The addiction of tumor cells to HSP90 has promoted...
3.
Grant M, Cavanaugh A, Breitwieser G
PLoS One
. 2015 Aug;
10(8):e0136702.
PMID: 26317416
Calcium sensing receptors (CaSR) interact with 14-3-3 binding proteins at a carboxyl terminal arginine-rich motif. Mutations identified in patients with familial hypocalciuric hypercalcemia, autosomal dominant hypocalcemia, pancreatitis or idiopathic epilepsy...
4.
Penrod Y, Rothblum K, Cavanaugh A, Rothblum L
Gene
. 2014 Sep;
556(1):61-7.
PMID: 25225125
Mammalian PAF49 and PAF53 form a heterodimer and are essential for transcription. However their roles in transcription have not been specifically defined. While the yeast homologues are "not essential" proteins,...
5.
Grant M, Stepanchick A, Cavanaugh A, Breitwieser G
Sci Signal
. 2011 Nov;
4(200):ra78.
PMID: 22114145
Calcium-sensing receptors (CaSRs) regulate systemic calcium homeostasis in the parathyroid gland, kidney, intestine, and bone and translate fluctuations in serum calcium into peptide hormone secretion, cell signaling, and regulation of...
6.
Huang Y, Cavanaugh A, Breitwieser G
Adv Pharmacol
. 2011 Sep;
62:143-73.
PMID: 21907909
Gain- or loss-of-function mutations and polymorphisms of the calcium-sensing receptor (CaSR) cause Ca(2+) handling diseases. Altered expression and/or signaling of wild-type CaSR can also contribute to pathology. Recent studies have...
7.
Cavanaugh A, Huang Y, Breitwieser G
Br J Pharmacol
. 2011 Apr;
165(6):1670-1677.
PMID: 21470201
Calcium-sensing receptors (CaSR) are integral to regulation of systemic Ca(2+) homeostasis. Altered expression levels or mutations in CaSR cause Ca(2+) handling diseases. CaSR is regulated by both endogenous allosteric modulators...
8.
Cavanaugh A, McKenna J, Stepanchick A, Breitwieser G
J Biol Chem
. 2010 Apr;
285(26):19854-64.
PMID: 20421307
Metabolic labeling with [(35)S]cysteine was used to characterize early events in CaSR biosynthesis. [(35)S]CaSR is relatively stable (half-life approximately 8 h), but maturation to the final glycosylated form is slow...
9.
White E, McKenna J, Cavanaugh A, Breitwieser G
Mol Endocrinol
. 2009 Apr;
23(7):1115-23.
PMID: 19389809
The calcium sensing receptor (CaSR) is a Family C/3 G protein-coupled receptor that translates changes in extracellular Ca(2+) into diverse intracellular signals. Loss-of-function mutations in human CaSR cause familial hypocalciuric...
10.
Hannan K, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, et al.
Mol Cell Biol
. 2003 Nov;
23(23):8862-77.
PMID: 14612424
Mammalian target of rapamycin (mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1. While each is known to...