Ali A Almaqwashi
Overview
Explore the profile of Ali A Almaqwashi including associated specialties, affiliations and a list of published articles.
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7
Citations
102
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Recent Articles
1.
Almaqwashi A, McCauley M, Andersson J, Rouzina I, Westerlund F, Lincoln P, et al.
Biophys J
. 2025 Jan;
124(4):667-676.
PMID: 39797403
Binuclear ruthenium complexes have been investigated for potential DNA-targeted therapeutic and diagnostic applications. Studies of DNA threading intercalation, in which DNA basepairs must be broken for intercalation, have revealed means...
2.
Almaqwashi A, Zhou W, Naufer M, Riddell I, Yilmaz O, Lippard S, et al.
J Am Chem Soc
. 2019 Jan;
141(4):1537-1545.
PMID: 30599508
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we used single-molecule studies...
3.
Almaqwashi A, Andersson J, Lincoln P, Rouzina I, Westerlund F, Williams M
Sci Rep
. 2016 Dec;
6:37993.
PMID: 27917863
The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for DNA-ligand assemblies. Unconventional intercalation mechanisms may exhibit...
4.
Almaqwashi A, Paramanathan T, Rouzina I, Williams M
Nucleic Acids Res
. 2016 Apr;
44(9):3971-88.
PMID: 27085806
There is a wide range of applications for non-covalent DNA binding ligands, and optimization of such interactions requires detailed understanding of the binding mechanisms. One important class of these ligands...
5.
Almaqwashi A, Andersson J, Lincoln P, Rouzina I, Westerlund F, Williams M
Biophys J
. 2016 Mar;
110(6):1255-63.
PMID: 27028636
DNA intercalators that have high affinity and slow kinetics are developed for potential DNA-targeted therapeutics. Although many natural intercalators contain multiple chiral subunits, only intercalators with a single chiral unit...
6.
Bahira M, McCauley M, Almaqwashi A, Lincoln P, Westerlund F, Rouzina I, et al.
Nucleic Acids Res
. 2015 Sep;
43(18):8856-67.
PMID: 26365236
Several multi-component DNA intercalating small molecules have been designed around ruthenium-based intercalating monomers to optimize DNA binding properties for therapeutic use. Here we probe the DNA binding ligand [μ-C4(cpdppz)2(phen)4Ru2](4+), which...
7.
Almaqwashi A, Paramanathan T, Lincoln P, Rouzina I, Westerlund F, Williams M
Nucleic Acids Res
. 2014 Sep;
42(18):11634-41.
PMID: 25245944
DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these properties, we utilize single molecule DNA stretching to quantify...
8.
Almaqwashi A, Kevek J, Burton R, Deborde T, Minot E
Nanotechnology
. 2011 May;
22(27):275717.
PMID: 21613731
Atomic force microscopy (AFM) performed with variable-force imaging was recently demonstrated to be an accurate method of determining the diameter and number of sidewalls of a carbon nanotube (CNT). This...