Alexia Kirby
Overview
Explore the profile of Alexia Kirby including associated specialties, affiliations and a list of published articles.
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12
Citations
41
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Recent Articles
1.
Calvert N, Baxter J, Torrens A, Thompson J, Kirby A, Walia J, et al.
Nat Nanotechnol
. 2024 Oct;
20(2):276-285.
PMID: 39468361
Currently, intravascular optical coherence tomography (IV-OCT) is limited to anatomical imaging, providing structural information about atherosclerotic plaque morphology, thrombus and dissection. Earlier detection and risk stratification would be possible through...
2.
Tracking the fate of bacteria-derived site-specific immunomodulators by positron emission tomography
Kirby A, Suchy M, Duan D, Bazett M, Kalyan S, Shuhendler A
Nucl Med Biol
. 2024 Apr;
132-133:108908.
PMID: 38599145
Introduction: Site-specific immunomodulators (SSIs) are a novel class of therapeutics made from inactivated bacterial species designed to regulate the innate immune system in targeted organs. QBECO is a gut-targeted SSI...
3.
Kirby A, Graf D, Suchy M, Calvert N, Charlton T, Ben R, et al.
J Nucl Med
. 2024 Jan;
65(3):475-480.
PMID: 38272705
Fructose metabolism has been implicated in various diseases, including metabolic disorders, neurodegenerative disorders, cardiac disorders, and cancer. However, the limited availability of a quantitative imaging radiotracer has hindered its exploration...
4.
Kirby A, Shuhendler A
Methods Mol Biol
. 2023 Nov;
2729:185-193.
PMID: 38006497
Positron emission tomography (PET) is a highly sensitive molecular imaging technique that uses radioactive tracers to map molecular and metabolic processes in living animals. PET can be performed as a...
5.
Gates E, Calvert N, Cundy N, Brugnoli F, Navals P, Kirby A, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628729
Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of...
6.
Calvert N, Kirby A, Suchy M, Pallister P, Torrens A, Burger D, et al.
Nat Commun
. 2023 Jul;
14(1):3965.
PMID: 37407664
Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing...
7.
Beland-Millar A, Kirby A, Truong Y, Ouellette J, Yandiev S, Bouyakdan K, et al.
Cell Rep
. 2023 May;
42(5):112485.
PMID: 37149866
Neurovascular abnormalities in mouse models of 16p11.2 deletion autism syndrome are reminiscent of alterations reported in murine models of glucose transporter deficiency, including reduced brain angiogenesis and behavioral alterations. Yet,...
8.
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Cheng H, Sebaa R, Malholtra N, Lacoste B, El Hankouri Z, Kirby A, et al.
Nat Commun
. 2021 Nov;
12(1):6801.
PMID: 34815412
Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body temperature (T) decreases via unknown mechanisms to conserve energy. In small mammals, non-shivering thermogenesis in brown adipose tissue...
9.
Brun E, Calvert N, Suchy M, Kirby A, Melkus G, Garipov R, et al.
Chem Commun (Camb)
. 2021 Oct;
57(83):10867-10870.
PMID: 34665184
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B metabolite necessary for >140 biotransformations was mapped by CEST-MRI and in...
10.
Vandewint A, Zhu-Pawlowsky A, Kirby A, Tattersall G, Pamenter M
J Therm Biol
. 2019 Aug;
84:228-235.
PMID: 31466758
Naked mole-rats are among the most hypoxia-tolerant mammals but have a poor thermoregulatory capacity due to their lack of insulating fur and fat, and small body size. In acute hypoxia,...