Alexey G Ryazanov
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Explore the profile of Alexey G Ryazanov including associated specialties, affiliations and a list of published articles.
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48
Citations
2631
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Recent Articles
1.
Smith P, Garcia G, Meyer A, Ryazanov A, Ma T, Loerch S, et al.
Mol Cell
. 2024 Dec;
85(4):756-769.e5.
PMID: 39694034
mRNA translation is integral to pain, yet the key regulatory factors and their target mRNAs are unclear. Here, we uncover a mechanism that bridges noxious insults to multiple phases of...
2.
Wang X, Yang Q, Zhou X, Keene C, Ryazanov A, Ma T
Alzheimers Dement
. 2024 Jun;
20(8):5357-5374.
PMID: 38934363
Introduction: Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments....
3.
Jana S, Brahma S, Arora S, Wladyka C, Hoang P, Blinka S, et al.
Cancer Cell
. 2023 Apr;
41(5):853-870.e13.
PMID: 37084735
We uncover a tumor-suppressive process in urothelium called transcriptional-translational conflict caused by deregulation of the central chromatin remodeling component ARID1A. Loss of Arid1a triggers an increase in a nexus of...
4.
Johnson J, Yaron T, Huntsman E, Kerelsky A, Song J, Regev A, et al.
Nature
. 2023 Jan;
613(7945):759-766.
PMID: 36631611
Protein phosphorylation is one of the most widespread post-translational modifications in biology. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and...
5.
Kasica N, Zhou X, Jester H, Holland C, Ryazanov A, Forshaw T, et al.
Front Aging Neurosci
. 2022 Sep;
14:959326.
PMID: 36158543
Maintenance of memory and synaptic plasticity depends on protein synthesis, and accumulating evidence implicates a role of dysregulated mRNA translation in cognitive impairments associated with Alzheimer's disease (AD). Accumulating evidence...
6.
Efimov A, Meshcheryakova O, Ryazanov A
Biochemistry (Mosc)
. 2022 Sep;
87(7):628-639.
PMID: 36154885
In this study, we conducted a comparative analysis of the structure of agonists and antagonists of transmembrane (TM) β-adrenoceptors (β-ARs) and their interactions with the β-ARs and proposed the mechanism...
7.
Rios F, Zou Z, Harvey A, Harvey K, Camargo L, Neves K, et al.
Commun Biol
. 2022 Jul;
5(1):746.
PMID: 35882956
Hyperaldosteronism causes cardiovascular disease as well as hypomagnesemia. Mechanisms are ill-defined but dysregulation of TRPM7, a Mg-permeable channel/α-kinase, may be important. We examined the role of TRPM7 in aldosterone-dependent cardiovascular...
8.
Kasica N, Zhou X, Yang Q, Wang X, Yang W, Zimmermann H, et al.
J Neurochem
. 2021 Dec;
160(5):524-539.
PMID: 34932218
It is imperative to develop novel therapeutic strategies for Alzheimer's disease (AD) and related dementia syndromes based on solid mechanistic studies. Maintenance of memory and synaptic plasticity relies on de...
9.
Yang W, Zhou X, Ryazanov A, Ma T
Neurobiol Aging
. 2020 Dec;
98:225-230.
PMID: 33341653
Impaired mRNA translation (protein synthesis) is linked to Alzheimer's disease (AD) pathophysiology. Recent studies revealed the role of increased phosphorylation of eukaryotic elongation factor 2 (eEF2) in AD-associated cognitive deficits....
10.
Gosrani S, Jester H, Zhou X, Ryazanov A, Ma T
Neurobiol Aging
. 2020 Aug;
95:154-160.
PMID: 32810756
The normal aging process is commonly associated with mild cognitive deficits including memory decline. Previous studies indicate a role of dysregulated messenger ribonucleic acid translation capacity in cognitive defects associated...