Alexei Degterev
Overview
Explore the profile of Alexei Degterev including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
87
Citations
8823
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, et al.
Eur J Med Chem
. 2021 Feb;
215:113252.
PMID: 33601309
Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD) cell signaling, a pathway implicated in numerous chronic inflammatory conditions. Herein, a...
12.
Muendlein H, Connolly W, Magri Z, Smirnova I, Ilyukha V, Gautam A, et al.
Nat Commun
. 2021 Jan;
12(1):86.
PMID: 33397971
Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly...
13.
Lule S, Wu L, Sarro-Schwartz A, Edmiston 3rd W, Izzy S, Songtachalert T, et al.
J Cereb Blood Flow Metab
. 2020 Nov;
41(7):1623-1633.
PMID: 33210566
Receptor-interacting protein kinase-1 (RIPK1) is a master regulator of cell death and inflammation, and mediates programmed necrosis (necroptosis) via mixed-lineage kinase like (MLKL) protein. Prior studies in experimental intracerebral hemorrhage...
14.
Cuny G, Degterev A
Semin Cell Dev Biol
. 2020 Aug;
109:96-105.
PMID: 32732131
Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases whose functions, regulation and pathophysiologic roles have remained an enigma for a long time. In recent years, these proteins...
15.
Suebsuwong C, Dai B, Pinkas D, Duddupudi A, Li L, Bufton J, et al.
Eur J Med Chem
. 2020 Jun;
200:112417.
PMID: 32505849
Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class of RIPK2...
16.
Muendlein H, Sarhan J, Liu B, Connolly W, Schworer S, Smirnova I, et al.
Cell Rep
. 2020 Jan;
30(3):699-713.e4.
PMID: 31968247
Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to...
17.
Degterev A, Ofengeim D, Yuan J
Proc Natl Acad Sci U S A
. 2019 May;
116(20):9714-9722.
PMID: 31048504
RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide range of human neurodegenerative, autoimmune, and inflammatory diseases. This was supported by extensive studies which...
18.
Saleh D, Degterev A
Methods Mol Biol
. 2018 Aug;
1857:19-33.
PMID: 30136227
Necroptosis is mediated by the formation of the detergent-insoluble necrosome complex between Ser/Thr kinases RIPK1 and RIPK3, which mediates RIPK3-dependent phosphorylation and activation of the critical necroptosis effector MLKL. Small...
19.
Hrdinka M, Schlicher L, Dai B, Pinkas D, Bufton J, Picaud S, et al.
EMBO J
. 2018 Jul;
37(17).
PMID: 30026309
RIPK2 mediates inflammatory signaling by the bacteria-sensing receptors NOD1 and NOD2. Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD-mediated pathologies. Here, we reveal that RIPK2 kinase activity...
20.
von Massenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, Rodriguez D, et al.
Cell Death Dis
. 2018 May;
9(6):622.
PMID: 29795371
The name of the one of the authors was misspelt. The author's surname is Rodriguez, not Rodriquez as originally published. This has been corrected in both the PDF and HTML...