Alexandre Marechal
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Explore the profile of Alexandre Marechal including associated specialties, affiliations and a list of published articles.
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31
Citations
2198
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Recent Articles
1.
Dubois J, Bonnell E, Filion A, Frion J, Zimmer S, Khan M, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2419712122.
PMID: 39772744
To achieve replicative immortality, cancer cells must activate telomere maintenance mechanisms. In 10 to 15% of cancers, this is enabled by recombination-based alternative lengthening of telomeres pathways (ALT). ALT cells...
2.
Kochman R, Ba I, Yates M, Pirabakaran V, Gourmelon F, Churikov D, et al.
Genes Dev
. 2024 Sep;
38(15-16):755-771.
PMID: 39231615
Premature telomere shortening or telomere instability is associated with a group of rare and heterogeneous diseases collectively known as telomere biology disorders (TBDs). Here we identified two unrelated individuals with...
3.
Djerir B, Marois I, Dubois J, Findlay S, Morin T, Senoussi I, et al.
J Biol Chem
. 2024 Jul;
300(8):107545.
PMID: 38992439
DNA double-strand breaks (DSBs) elicit an elaborate response to signal damage and trigger repair via two major pathways: nonhomologous end-joining (NHEJ), which functions throughout the interphase, and homologous recombination (HR),...
4.
Yates M, Marois I, St-Hilaire E, Ronato D, Djerir B, Brochu C, et al.
PLoS Biol
. 2024 Mar;
22(3):e3002552.
PMID: 38502677
Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early...
5.
Fauteux M, Cote N, Bergeron S, Marechal A, Gaudreau L
Sci Rep
. 2023 Dec;
13(1):21211.
PMID: 38040841
As modern agricultural practices increase their use of chemical pesticides, it is inevitable that we will find a number of these xenobiotics within drinking water supplies and disseminated throughout the...
6.
Vickridge E, Faraco C, Lo F, Rahimian H, Liu Z, Tehrani P, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):223-242.
PMID: 37956270
Genetic studies in mice and human cancers established BCL11B as a haploinsufficient tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers where its knockdown is synthetic lethal. We...
7.
Casimir L, Zimmer S, Racine-Brassard F, Goudreau F, Jacques P, Marechal A
Mutat Res
. 2023 Aug;
827:111834.
PMID: 37531716
DNA replication stress (RS) entails the frequent slow down and arrest of replication forks by a variety of conditions that hinder accurate and processive genome duplication. Elevated RS leads to...
8.
Casimir L, Zimmer S, Racine-Brassard F, Jacques P, Marechal A
DNA Repair (Amst)
. 2022 Dec;
122:103433.
PMID: 36566616
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties. Early genetic studies and more recent genome-wide CRISPR screens showed that Illudin-induced lesions are preferentially...
9.
Idrissou M, Marechal A
Cancers (Basel)
. 2022 Feb;
14(4).
PMID: 35205626
mRNA processing factors are increasingly being recognized as important regulators of genome stability. By preventing and resolving RNA:DNA hybrids that form co-transcriptionally, these proteins help avoid replication-transcription conflicts and thus...
10.
Heath J, Simo Cheyou E, Findlay S, Luo V, Carpio E, Lee J, et al.
EMBO Rep
. 2021 Nov;
23(1):e51041.
PMID: 34758190
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger...