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Alexandre de Mendonca

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Articles 186
Citations 5502
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Recent Articles
1.
Sogorb-Esteve A, Weiner S, Simren J, Swift I, Bocchetta M, Todd E, et al.
Sci Transl Med . 2025 Feb; 17(784):eadm9654. PMID: 39908349
We used an untargeted mass spectrometric approach, tandem mass tag proteomics, for the identification of proteomic signatures in genetic frontotemporal dementia (FTD). A total of 238 cerebrospinal fluid (CSF) samples...
2.
Lentzen M, Vairavan S, Muurling M, Alepopoulos V, Atreya A, Boada M, et al.
Alzheimers Res Ther . 2025 Jan; 17(1):29. PMID: 39865315
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, leading to cognitive and functional decline. Early detection and intervention are crucial for enhancing the quality of life...
3.
Wiels W, Oomens J, Engelborghs S, Baeken C, von Arnim C, Boada M, et al.
JAMA Psychiatry . 2025 Jan; 82(3):296-310. PMID: 39841452
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive...
4.
Fonseca-Gomes J, Costa-Coelho T, Ferreira-Manso M, Inteiro-Oliveira S, Vaz S, Aleman-Serrano N, et al.
Mol Ther . 2024 Dec; 33(1):421. PMID: 39672159
No abstract available.
5.
Rune Nielsen T, de Mendonca A, Frolich L, Engelborghs S, Gove D, Lamirel D, et al.
Int J Geriatr Psychiatry . 2024 Dec; 39(12):e70034. PMID: 39663199
Objectives: There is no European consensus on good clinical practice for timely diagnosis and culturally appropriate care of people with dementia from minority ethnic groups. Despite significant advances in culture-sensitive...
6.
Pestana P, Cardoso S, Guerreiro M, Maroco J, Jessen F, Simoes do Couto F, et al.
Alzheimers Res Ther . 2024 Dec; 16(1):261. PMID: 39639343
Background: Subjective Cognitive Decline (SCD) is recognized as a risk stage for future cognitive impairment and dementia. The criteria for SCD include normal performance on neuropsychological testing; however, there is...
7.
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi S, et al.
Mol Psychiatry . 2024 Dec; PMID: 39633006
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of...
8.
Best P, Van Swieten J, Jiskoot L, Moreno F, Sanchez-Valle R, Laforce Jr R, et al.
Neurology . 2024 Nov; 103(11):e209829. PMID: 39527773
Background And Objectives: Sleep dysfunction is common in patients with neurodegenerative disorders; however, its neural underpinnings remain poorly characterized in genetic frontotemporal dementia (FTD). Hypothalamic nuclei important for sleep regulation...
9.
Borrego-Ecija S, Junca-Parella J, Vandebergh M, Perez Millan A, Balasa M, Llado A, et al.
Neurology . 2024 Nov; 103(11):e209944. PMID: 39527772
Background And Objectives: Pathogenic variants in the gene cause frontotemporal dementia (FTD-) with marked brain asymmetry. This study aims to assess whether the disease progression of FTD- depends on the...
10.
Anjos R, Madruga N, Cardoso S, Schmand B, Guerreiro M, de Mendonca A, et al.
Int J Geriatr Psychiatry . 2024 Oct; 39(11):e70007. PMID: 39472311
Introduction: Patients with Alzheimer's disease (AD), namely at an initial stage like amnestic cognitive impairment (aMCI), typically present with memory complaints. They also have difficulties regarding self-knowledge about their cognitive...