Alexandra R Grassian
Overview
Explore the profile of Alexandra R Grassian including associated specialties, affiliations and a list of published articles.
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13
Citations
1744
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Recent Articles
1.
Brown V, Moore S, Chen M, House N, Ramsden P, Wu H, et al.
NAR Cancer
. 2023 Jul;
5(3):zcad039.
PMID: 37519629
amplification is a common alteration in high-grade serous ovarian cancer and occurs in 15-20% of these tumors. These amplifications are mutually exclusive with homologous recombination deficiency, and, as they have...
2.
Thomenius M, Totman J, Harvey D, Mitchell L, Riera T, Cosmopoulos K, et al.
PLoS One
. 2018 Jun;
13(6):e0197372.
PMID: 29856759
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular...
3.
Chan-Penebre E, Armstrong K, Drew A, Grassian A, Feldman I, Knutson S, et al.
Mol Cancer Ther
. 2017 Mar;
16(5):850-860.
PMID: 28292935
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit...
4.
Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al.
PLoS One
. 2017 Jan;
12(1):e0170539.
PMID: 28085948
[This corrects the article DOI: 10.1371/journal.pone.0158888.].
5.
Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al.
PLoS One
. 2016 Jul;
11(7):e0158888.
PMID: 27391784
The catalytic activities of covalent and ATP-dependent chromatin remodeling are central to regulating the conformational state of chromatin and the resultant transcriptional output. The enzymes that catalyze these activities are...
6.
Grassian A, Parker S, Davidson S, Divakaruni A, Green C, Zhang X, et al.
Cancer Res
. 2014 Apr;
74(12):3317-31.
PMID: 24755473
Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study,...
7.
Grassian A, Pagliarini R, Chiang D
Curr Opin Gastroenterol
. 2014 Feb;
30(3):295-302.
PMID: 24569570
Purpose Of Review: Exome sequencing studies have recently expanded the genetic characterization of intrahepatic cholangiocarcinomas. Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrently mutated in intrahepatic cholangiocarcinomas....
8.
Grassian A, Lin F, Barrett R, Liu Y, Jiang W, Korpal M, et al.
J Biol Chem
. 2012 Oct;
287(50):42180-94.
PMID: 23038259
Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types, resulting in production of the proposed oncometabolite, 2-hydroxyglutarate (2-HG). How mutant IDH...
9.
Grassian A, Metallo C, Coloff J, Stephanopoulos G, Brugge J
Genes Dev
. 2011 Aug;
25(16):1716-33.
PMID: 21852536
Loss of extracellular matrix (ECM) attachment leads to metabolic impairments that limit cellular energy production. Characterization of the metabolic alterations induced by ECM detachment revealed a dramatic decrease in uptake...
10.
Locasale J, Grassian A, Melman T, Lyssiotis C, Mattaini K, Bass A, et al.
Nat Genet
. 2011 Aug;
43(9):869-74.
PMID: 21804546
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood. Using a metabolomics approach with isotope...