Alexandra M Fajardo
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Explore the profile of Alexandra M Fajardo including associated specialties, affiliations and a list of published articles.
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6
Citations
155
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Recent Articles
1.
Fajardo A, MacKenzie D, Olguin S, Scariano J, Rabinowitz I, Thompson T
PLoS One
. 2016 Mar;
11(3):e0151525.
PMID: 26986969
Tocopherylquinone (TQ), the oxidation product of alpha-tocopherol (AT), is a bioactive molecule with distinct properties from AT. In this study, AT and TQ are investigated for their comparative effects on...
2.
Fajardo A, Piazza G
Am J Physiol Gastrointest Liver Physiol
. 2015 May;
309(2):G59-70.
PMID: 26021807
Colorectal cancer (CRC) is one of the most common human malignancies and a leading cause of cancer-related deaths in developed countries. Identifying effective preventive strategies aimed at inhibiting the development...
3.
Fajardo A, Piazza G, Tinsley H
Cancers (Basel)
. 2014 Mar;
6(1):436-58.
PMID: 24577242
For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides...
4.
Ahmed N, H Ali A, El-Nashar S, Gary B, Fajardo A, Tinsley H, et al.
Eur J Med Chem
. 2012 Nov;
57:329-43.
PMID: 23117589
By studying the co-crystal information of interactions between PDE5 and its inhibitors, forty new tetrahydro-β-carbolines based-analogues were synthesized, and tested for their PDE5 inhibition. Some compounds were as active as...
5.
Fajardo A, MacKenzie D, Ji M, Deck L, Vander Jagt D, Thompson T, et al.
Prostate
. 2011 Jul;
72(6):612-25.
PMID: 21796654
Background: The androgen receptor (AR) plays a critical role in prostate cancer development and progression. Therefore, the inhibition of AR function is an established therapeutic intervention. Since the expression of...
6.
Hines W, Fajardo A, Joste N, Bisoffi M, Griffith J
Mol Cancer Res
. 2005 Sep;
3(9):503-9.
PMID: 16179497
The enzyme telomerase catalyzes the de novo synthesis of telomere repeats, thereby maintaining telomere length, which is necessary for unlimited cellular proliferation. Telomerase reverse transcriptase (TERT), the catalytic domain of...