Alexandra Koschak
Overview
Explore the profile of Alexandra Koschak including associated specialties, affiliations and a list of published articles.
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38
Citations
1804
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Recent Articles
1.
Heigl T, Netzer M, Zanetti L, Ganglberger M, Fernandez-Quintero M, Koschak A
Channels (Austin)
. 2023 Mar;
17(1):2192360.
PMID: 36943941
Cav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, , can cause congenital stationary night-blindness type 2...
2.
Seitter H, Obkircher J, Grabher P, Hartl J, Zanetti L, Lux U, et al.
J Biol Chem
. 2023 Feb;
299(4):102972.
PMID: 36738788
Cavβ subunits are essential for surface expression of voltage-gated calcium channel complexes and crucially modulate biophysical properties like voltage-dependent inactivation. Here, we describe the discovery and characterization of a novel...
3.
Le N, Zsak S, Le-Vinh B, Friedl J, Kali G, Knoll P, et al.
ACS Appl Mater Interfaces
. 2022 Sep;
14(39):44981-44991.
PMID: 36125912
Aim: This study aimed to develop phosphatase-responsive ζ potential converting nanocarriers utilizing polyphosphate-coated cell-penetrating peptide (CPP)-decorated nanoemulsions (NEs) as a novel gene delivery system to retinal cells. Methods: Poly-l-lysine (PLL)...
4.
Kilicarslan I, Zanetti L, Novelli E, Schwarzer C, Strettoi E, Koschak A
Sci Rep
. 2021 Jul;
11(1):15146.
PMID: 34312410
Retinitis Pigmentosa is a genetically heterogeneous, degenerative retinal disorder characterized by gradual dysfunction and death of photoreceptors, first rods and later cones, and progressive blindness. Studies suggested that application of...
5.
Koschak A, Fernandez-Quintero M, Heigl T, Ruzza M, Seitter H, Zanetti L
Pflugers Arch
. 2021 Jul;
473(9):1437-1454.
PMID: 34212239
Cav1.4 L-type Ca channels are predominantly expressed in retinal neurons, particularly at the photoreceptor terminals where they mediate sustained Ca entry needed for continuous neurotransmitter release at their ribbon synapses....
6.
Zanetti L, Kilicarslan I, Netzer M, Babai N, Seitter H, Koschak A
Sci Rep
. 2021 Feb;
11(1):2732.
PMID: 33526839
Ca1.4 L-type calcium channels are predominantly expressed in photoreceptor terminals playing a crucial role for synaptic transmission and, consequently, for vision. Human mutations in the encoding gene are associated with...
7.
Kaehler K, Seitter H, Sandbichler A, Tschugg B, Obermair G, Stefanova N, et al.
Invest Ophthalmol Vis Sci
. 2020 Jun;
61(6):12.
PMID: 32503050
Purpose: Synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease are associated with a variety of visual symptoms. Functional and morphological retinal aberrations are therefore supposed to be valuable...
8.
Pangrsic T, Singer J, Koschak A
Physiol Rev
. 2018 Aug;
98(4):2063-2096.
PMID: 30067155
Calcium influx through voltage-gated Ca (Ca) channels is the first step in synaptic transmission. This review concerns Ca channels at ribbon synapses in primary sense organs and their specialization for...
9.
Zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, et al.
J Clin Invest
. 2018 Mar;
128(5):2076-2088.
PMID: 29494346
Increasing evidence suggests that synapse dysfunctions are a major determinant of several neurodevelopmental and neurodegenerative diseases. Here we identify protein kinase N1 (PKN1) as a novel key player in fine-tuning...
10.
Seitter H, Koschak A
Neuropharmacology
. 2017 Jul;
132:58-70.
PMID: 28669898
Channelopathies are a diverse group of human disorders that are caused by mutations in genes coding for ion channels or channel-regulating proteins. Several dozen channelopathies have been identified that involve...