Alexandra Faustino
Overview
Explore the profile of Alexandra Faustino including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
165
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0
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Recent Articles
1.
Varland S, Silva R, Kjosas I, Faustino A, Bogaert A, Billmann M, et al.
Nat Commun
. 2023 Oct;
14(1):6774.
PMID: 37891180
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic...
2.
Casalou C, Faustino A, Silva F, Ferreira I, Vaqueirinho D, Ferreira A, et al.
Cancers (Basel)
. 2019 Oct;
11(10).
PMID: 31569511
Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors' ability to form metastases....
3.
Casalou C, Faustino A, Barral D
Small GTPases
. 2016 Sep;
7(4):270-282.
PMID: 27589148
Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including...
4.
Rathore O, Faustino A, Prudencio P, Van Damme P, Cox C, Martinho R
Sci Rep
. 2016 Feb;
6:21304.
PMID: 26861501
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six...
5.
Populo H, Tavares S, Faustino A, Nunes J, Lopes J, Soares P
PeerJ
. 2013 Aug;
1:e104.
PMID: 23904987
Somatic mutations in GNAQ gene were described as being the main oncogenic activation in uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic alteration that...
6.
Celestino R, Lima J, Faustino A, Vinagre J, Maximo V, Gouveia A, et al.
Eur J Hum Genet
. 2012 Sep;
21(5):503-10.
PMID: 22948025
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, disclosing somatic KIT, PDGFRA and BRAF mutations. Loss of function of succinate dehydrogenase (SDH) complex is...
7.
Smoking is a predictor of worse trabecular mechanical performance in hip fragility fracture patients
Rodrigues A, Caetano-Lopes J, Vale A, Aleixo I, Pena A, Faustino A, et al.
J Bone Miner Metab
. 2012 Aug;
30(6):692-9.
PMID: 22886402
Clinical risk factors (CRFs) are established predictors of fracture events. However, the influence of individual CRFs on trabecular mechanical fragility is still a subject of debate. In this study, we...
8.
Faustino A, Couto J, Populo H, Rocha A, Pardal F, Cameselle-Teijeiro J, et al.
J Clin Endocrinol Metab
. 2012 May;
97(7):E1139-49.
PMID: 22549934
Context: There are several genetic and molecular evidences suggesting dysregulation of the mammalian target of rapamycin (mTOR) pathway in thyroid neoplasia. Activation of the phosphatidylinositol-3-kinase/AKT pathway by RET/PTC and mutant...
9.
Celestino R, Lima J, Faustino A, Maximo V, Gouveia A, Vinagre J, et al.
Fam Cancer
. 2011 Dec;
11(2):189-94.
PMID: 22160509
Gastrointestinal stromal tumors (GISTs) are the most common mesenchyme neoplasms of the gastrointestinal tract. Gain-of-function somatic mutations of the KIT or PDGFRA genes represent the most prevalent molecular alterations in...