Alexander V Strunnikov
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Explore the profile of Alexander V Strunnikov including associated specialties, affiliations and a list of published articles.
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16
Citations
416
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Recent Articles
1.
Pugacheva E, Bhatt D, Rivero-Hinojosa S, Tajmul M, Fedida L, Price E, et al.
Genome Biol
. 2024 Jan;
25(1):40.
PMID: 38297316
Background: Pervasive usage of alternative promoters leads to the deregulation of gene expression in carcinogenesis and may drive the emergence of new genes in spermatogenesis. However, little is known regarding...
2.
Boukaba A, Wu Q, Liu J, Chen C, Liang J, Li J, et al.
NAR Genom Bioinform
. 2022 Nov;
4(4):lqac085.
PMID: 36415827
Separase is a protease that performs critical functions in the maintenance of genetic homeostasis. Among them, the cleavage of the meiotic cohesin during meiosis is a key step in producing...
3.
Boukaba A, Liu J, Ward C, Wu Q, Arnaoutov A, Liang J, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(40):e2204071119.
PMID: 36179046
Many tumors express meiotic genes that could potentially drive somatic chromosome instability. While germline cohesin subunits SMC1B, STAG3, and REC8 are widely expressed in many cancers, messenger RNA and protein...
4.
Rivero-Hinojosa S, Pugacheva E, Kang S, Mendez-Catala C, Kovalchuk A, Strunnikov A, et al.
Nat Commun
. 2021 Jun;
12(1):3846.
PMID: 34158481
CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer states. Unexpectedly, BORIS-null...
5.
Pugacheva E, Kubo N, Loukinov D, Tajmul M, Kang S, Kovalchuk A, et al.
Proc Natl Acad Sci U S A
. 2020 Jan;
117(4):2020-2031.
PMID: 31937660
The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we...
6.
Pugacheva E, Rivero-Hinojosa S, Espinoza C, Mendez-Catala C, Kang S, Suzuki T, et al.
Genome Biol
. 2015 Aug;
16:161.
PMID: 26268681
Background: CTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation....
7.
Samoshkin A, Dulev S, Loukinov D, Rosenfeld J, Strunnikov A
Chromosoma
. 2011 Dec;
121(2):191-9.
PMID: 22179743
Condensin complexes are essential for chromosome condensation and segregation in mitosis, while condensin dysfunction, among other pathways leading to chromosomal bridging in mitosis, may play a role in tumor genomic...
8.
Pugacheva E, Suzuki T, Pack S, Kosaka-Suzuki N, Yoon J, Vostrov A, et al.
PLoS One
. 2010 Nov;
5(11):e13872.
PMID: 21079786
Background: BORIS/CTCFL is a paralogue of CTCF, the major epigenetic regulator of vertebrate genomes. BORIS is normally expressed only in germ cells but is aberrantly activated in numerous cancers. While...
9.
Strunnikov A
Cell Div
. 2010 May;
5(1):15.
PMID: 20482869
Recent data show that cells from many cancers exhibit massive chromosome instability. The traditional view is that the gradual accumulation of mutations in genes involved in transcriptional regulation and cell...
10.
Takahashi Y, Iwase M, Strunnikov A, Kikuchi Y
Cell Cycle
. 2008 Jun;
7(12):1738-44.
PMID: 18583943
SUMO (small ubiquitin-related modifier), a 12 kDa protein with distant similarity to ubiquitin, covalently binds to many proteins in eukaryotic cells. In contrast to ubiquitination, which mainly regulates proteasome-dependent degradation...