Alexander L Kovalchuk
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Explore the profile of Alexander L Kovalchuk including associated specialties, affiliations and a list of published articles.
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37
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1069
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Recent Articles
1.
Stepanov G, Penkov N, Rodionova N, Petrova A, Kozachenko A, Kovalchuk A, et al.
Front Chem
. 2024 Oct;
12:1456533.
PMID: 39391834
The advancement of experimental methods has provided new information about the structure and structural fluctuations of water. Despite the appearance of numerous models, which aim to describe a wide range...
2.
Ledov V, Golovina M, Alkhazova B, Lvov V, Kovalchuk A, Aparin P
Vaccines (Basel)
. 2023 Feb;
11(2).
PMID: 36851223
A multivalent vaccine is much needed to achieve protection against predominant serotypes. Recently, we demonstrated the clinical applicability and immunogenic potential of tri-acylated 2a lipopolysaccharide (Ac-S-LPS). Using a similar approach,...
3.
Dyatlov I, Svetoch E, Mironenko A, Eruslanov B, Firstova V, Fursova N, et al.
Vaccines (Basel)
. 2022 Nov;
10(11).
PMID: 36366362
Background: Shiga toxin-producing (STEC) O157:H7 and O104:H4 strains are important causative agents of food-borne diseases such as hemorrhagic colitis and hemolytic-uremic syndrome, which is the leading cause of kidney failure...
4.
Rivero-Hinojosa S, Pugacheva E, Kang S, Mendez-Catala C, Kovalchuk A, Strunnikov A, et al.
Nat Commun
. 2021 Jun;
12(1):3846.
PMID: 34158481
CTCF is a key organizer of the 3D genome. Its specialized paralog, BORIS, heterodimerizes with CTCF but is expressed only in male germ cells and in cancer states. Unexpectedly, BORIS-null...
5.
Gary J, Simmons J, Xu J, Zhang S, Peat T, Watson N, et al.
Mol Cancer Ther
. 2020 Aug;
19(10):2221-2232.
PMID: 32747423
PI3K/AKT/mTOR pathway hyperactivation is frequent in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL). To model inhibition of mTOR, pre-T-cell lymphoblastic leukemia/lymphoma (pre-T LBL) tumor development was monitored in mice with T lymphocyte-specific,...
6.
Tarasov S, Gorbunov E, Don E, Emelyanova A, Kovalchuk A, Yanamala N, et al.
J Immunol
. 2020 Jul;
205(5):1345-1354.
PMID: 32727888
The therapeutic use of Abs in cancer, autoimmunity, transplantation, and other fields is among the major biopharmaceutical advances of the 20th century. Broader use of Ab-based drugs is constrained because...
7.
Pugacheva E, Kubo N, Loukinov D, Tajmul M, Kang S, Kovalchuk A, et al.
Proc Natl Acad Sci U S A
. 2020 Jan;
117(4):2020-2031.
PMID: 31937660
The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we...
8.
Wang H, Jain S, Li P, Lin J, Oh J, Qi C, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(19):9511-9520.
PMID: 31000603
The IRF and Ets families of transcription factors regulate the expression of a range of genes involved in immune cell development and function. However, the understanding of the molecular mechanisms...
9.
Ledov V, Golovina M, Markina A, Knirel Y, Lvov V, Kovalchuk A, et al.
Vaccine
. 2019 Jan;
37(8):1062-1072.
PMID: 30670300
Shigellosis, a major cause of diarrhea worldwide, exhibits high morbidity and mortality in children. Specificity of Shigella immunity is determined by the structure of the main protective O-antigen polysaccharide component...
10.
Kovalchuk A, Sakai T, Qi C, du Bois W, Dunnick W, Cogne M, et al.
Oncotarget
. 2018 Oct;
9(77):34528-34542.
PMID: 30349647
-deregulating T(12;15) chromosomal translocations are the hallmark cytogenetic abnormalities of murine plasmacytomas (PCTs). In most PCTs, the immunoglobulin heavy chain () locus is broken between the enhancer and the 3'...