Abdelhalim Boukaba
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Explore the profile of Abdelhalim Boukaba including associated specialties, affiliations and a list of published articles.
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12
Citations
399
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Recent Articles
1.
Boukaba A, Wu Q, Liu J, Chen C, Liang J, Li J, et al.
NAR Genom Bioinform
. 2022 Nov;
4(4):lqac085.
PMID: 36415827
Separase is a protease that performs critical functions in the maintenance of genetic homeostasis. Among them, the cleavage of the meiotic cohesin during meiosis is a key step in producing...
2.
Boukaba A, Liu J, Ward C, Wu Q, Arnaoutov A, Liang J, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(40):e2204071119.
PMID: 36179046
Many tumors express meiotic genes that could potentially drive somatic chromosome instability. While germline cohesin subunits SMC1B, STAG3, and REC8 are widely expressed in many cancers, messenger RNA and protein...
3.
Teplyakov E, Wu Q, Liu J, Pugacheva E, Loukinov D, Boukaba A, et al.
Oncotarget
. 2017 Nov;
8(43):73448-73468.
PMID: 29088719
The gene, is a testis-specific paralog frequently erroneously activated in cancer, although its exact role in cancer remains unclear. BORIS is both a transcription factor and an architectural chromatin protein....
4.
Pugacheva E, Teplyakov E, Wu Q, Li J, Chen C, Meng C, et al.
Epigenetics Chromatin
. 2016 Sep;
9(1):35.
PMID: 27588042
Background: A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription...
5.
Pugacheva E, Rivero-Hinojosa S, Espinoza C, Mendez-Catala C, Kang S, Suzuki T, et al.
Genome Biol
. 2015 Aug;
16:161.
PMID: 26268681
Background: CTCF and BORIS (CTCFL), two paralogous mammalian proteins sharing nearly identical DNA binding domains, are thought to function in a mutually exclusive manner in DNA binding and transcriptional regulation....
6.
Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, et al.
Cell Rep
. 2014 Jul;
8(3):743-53.
PMID: 25066127
DNA methylation is a central epigenetic modification that is established by de novo DNA methyltransferases. The mechanisms underlying the generation of genomic methylation patterns are still poorly understood. Using mass...
7.
Simmer F, Buscaino A, Kos-Braun I, Kagansky A, Boukaba A, Urano T, et al.
EMBO Rep
. 2010 Jan;
11(2):112-8.
PMID: 20062003
RNA interference (RNAi) is widespread in eukaryotes and regulates gene expression transcriptionally or post-transcriptionally. In fission yeast, RNAi is tightly coupled to template transcription and chromatin modifications that establish heterochromatin...
8.
Kagansky A, Folco H, Almeida R, Pidoux A, Boukaba A, Simmer F, et al.
Science
. 2009 Jun;
324(5935):1716-9.
PMID: 19556509
In the central domain of fission yeast centromeres, the kinetochore is assembled on CENP-A(Cnp1) nucleosomes. Normally, small interfering RNAs generated from flanking outer repeat transcripts direct histone H3 lysine 9...
9.
Opel M, Lando D, Bonilla C, Trewick S, Boukaba A, Walfridsson J, et al.
PLoS One
. 2007 Apr;
2(4):e386.
PMID: 17440621
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues...
10.
Rodriguez J, Boukaba A, Sandoval J, Georgieva E, Latasa M, Garcia-Trevijano E, et al.
Int J Biochem Cell Biol
. 2007 Feb;
39(4):842-50.
PMID: 17317269
Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S-adenosylmethionine, the main methyl donor. Two MAT-encoding genes (MAT1A, MAT2A) are found in mammals. The latter is...