Alexander Stark
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Explore the profile of Alexander Stark including associated specialties, affiliations and a list of published articles.
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110
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17883
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Recent Articles
1.
Thomas H, Feng S, Haslhofer F, Huber M, Garcia Gallardo M, Loubiere V, et al.
Mol Cell
. 2024 Dec;
85(2):362-375.e9.
PMID: 39626663
Enhancers are short DNA sequences that activate their target promoter from a distance; however, increasing the genomic distance between the enhancer and the promoter decreases expression levels. Many genes are...
2.
Choi J, Im H, Heo J, Kim D, Jiang H, Stark A, et al.
Nat Commun
. 2024 Dec;
15(1):10282.
PMID: 39622817
Efficient light generation from triplet states of organic molecules has been a hot yet demanding topic in academia and the display industry. Herein, we propose a strategy for developing triplet...
3.
Hofbauer L, Pleyer L, Reiter F, Schleiffer A, Vlasova A, Serebreni L, et al.
Mol Cell
. 2024 Nov;
84(23):4503-4521.e14.
PMID: 39571581
Differential gene transcription enables development and homeostasis in all animals and is regulated by two major classes of distal cis-regulatory DNA elements (CREs): enhancers and silencers. Although enhancers have been...
4.
Loubiere V, de Almeida B, Pagani M, Stark A
Nat Commun
. 2024 Oct;
15(1):8584.
PMID: 39362902
Genomic enhancers are key transcriptional regulators which, upon the binding of sequence-specific transcription factors, activate their cognate target promoters. Although enhancers have been extensively studied in isolation, a substantial number...
5.
Glargaard S, Deis T, Abild-Nielsen A, Stark A, Thomsen J, Kristensen S, et al.
Circ Heart Fail
. 2024 Aug;
17(9):e011253.
PMID: 39105292
Background: Pleural effusion is present in 50% to 80% of patients with acute heart failure, depending on image modality. We aim to describe the association between the presence and size...
6.
Nemcko F, Himmelsbach M, Loubiere V, Yelagandula R, Pagani M, Fasching N, et al.
Nat Methods
. 2024 Jul;
21(9):1668-1673.
PMID: 38969721
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present ORFtag, a versatile, cost-effective and highly efficient method...
7.
Frank O, Balboa D, Novatchkova M, Ozkan E, Strobl M, Yelagandula R, et al.
Euro Surveill
. 2024 Jun;
29(23).
PMID: 38847119
BackgroundThe COVID-19 pandemic was largely driven by genetic mutations of SARS-CoV-2, leading in some instances to enhanced infectiousness of the virus or its capacity to evade the host immune system....
8.
de Almeida B, Schaub C, Pagani M, Secchia S, Furlong E, Stark A
Nature
. 2023 Dec;
626(7997):207-211.
PMID: 38086418
Enhancers control gene expression and have crucial roles in development and homeostasis. However, the targeted de novo design of enhancers with tissue-specific activities has remained challenging. Here we combine deep...
9.
Jacobs J, Pagani M, Wenzl C, Stark A
Science
. 2023 Jul;
381(6654):198-204.
PMID: 37440660
Gene expression is controlled by the precise activation and repression of transcription. Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors (CoRs) to silence transcription, even in the...
10.
Chan Y, Kienle E, Oti M, Di Liddo A, Mendez-Lago M, Aschauer D, et al.
Sci Rep
. 2023 May;
13(1):6745.
PMID: 37185990
Enhancers are important cis-regulatory elements controlling cell-type specific expression patterns of genes. Furthermore, combinations of enhancers and minimal promoters are utilized to construct small, artificial promoters for gene delivery vectors....