Alexander Sorkin
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Explore the profile of Alexander Sorkin including associated specialties, affiliations and a list of published articles.
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95
Citations
5034
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Recent Articles
1.
Pinilla-Macua I, Surve S, Sorkin A
J Cell Sci
. 2025 Jan;
138(2).
PMID: 39744818
Ligand binding to EGFR activates Rho family GTPases, triggering actin cytoskeleton reorganization, cell migration and invasion. Activated EGFR is also rapidly endocytosed but the role of EGFR endocytosis in cell...
2.
Sorkina T, Bagalkot T, Cheng M, Guthrie D, Newman A, Watkins S, et al.
Sci Adv
. 2024 Nov;
10(47):eadq9793.
PMID: 39576869
Monoamine transporters function in neuronal membranes to control extracellular concentrations of their substrates. Cell-surface expression of transporters is regulated by substrates and intracellular signaling, but the underlying mechanisms remain unclear....
3.
Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, et al.
Cell Rep
. 2024 Nov;
43(11):114986.
PMID: 39546398
Canonical epidermal growth factor (EGF) receptor (EGFR) activation involves the binding of seven EGFR ligands (EGFRLs); however, their extracellular dynamics remain elusive. Here, employing fluorescent probes and a tool for...
4.
Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, et al.
bioRxiv
. 2024 Oct;
PMID: 39399773
Epidermal growth factor receptor ligands (EGFRLs) consist of seven proteins. In stark contrast to the amassed knowledge concerning the epidermal growth factor receptors themselves, the extracellular dynamics of individual EGFRLs...
5.
Bagalkot T, Sorkin A
eNeuro
. 2024 Jan;
11(1).
PMID: 38164591
Dopamine transporter (DAT) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. DAT is a target of abused psychostimulants such as amphetamine (Amph). Acute Amph administration...
6.
Pinilla-Macua I, Sorkin A
Mol Biol Cell
. 2023 Oct;
34(13):ar134.
PMID: 37903221
Highly homologous E3 ubiquitin ligases, Cbl and Cbl-b, mediate ubiquitination of EGF receptor (EGFR), leading to its endocytosis and lysosomal degradation. Cbl and Cbl-b, are thought to function in a...
7.
Small C, Cheng M, Belay S, Bulloch S, Zimmerman B, Sorkin A, et al.
J Pharmacol Exp Ther
. 2023 Jun;
386(2):266-273.
PMID: 37348963
The alkylamine stimulant 1,3-dimethylamylamine (DMAA) is used nonmedically as an appetite suppressant and exercise performance enhancer despite adverse cardiovascular effects that have limited its legal status. There is scant research...
8.
Bagalkot T, Sorkin A
bioRxiv
. 2023 Jun;
PMID: 37293021
Dopamine transporter (DAT) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. DAT is a target of abused psychostimulants such as amphetamine (Amph). Acute Amph is...
9.
Surve S, Sorkin A
Bio Protoc
. 2022 Jul;
12(10):e4415.
PMID: 35813028
Subcellular localization dynamics of proteins involved in signal transduction processes is crucial in determining the signaling outcome. However, there is very limited information about the localization of endogenous signaling proteins...
10.
Perez Verdaguer M, Zhang T, Surve S, Paulo J, Wallace C, Watkins S, et al.
Cell Rep
. 2022 Jun;
39(11):110950.
PMID: 35705039
Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its cross-talk with signaling are poorly understood....