Lai Kuan Goh
Overview
Explore the profile of Lai Kuan Goh including associated specialties, affiliations and a list of published articles.
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6
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928
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Recent Articles
1.
Goh L, Sorkin A
Cold Spring Harb Perspect Biol
. 2013 May;
5(5):a017459.
PMID: 23637288
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the...
2.
Goh L, Huang F, Kim W, Gygi S, Sorkin A
J Cell Biol
. 2010 Jun;
189(5):871-83.
PMID: 20513767
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis mechanisms are poorly understood, which precludes development of approaches to specifically...
3.
Sorkin A, Goh L
Exp Cell Res
. 2009 Mar;
315(4):683-96.
PMID: 19278030
This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR...
4.
Sorkin A, Goh L
Exp Cell Res
. 2008 Sep;
314(17):3093-106.
PMID: 18793634
This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR...
5.
Noble S, Allen B, Goh L, Nordick K, Evans T
J Cell Biol
. 2008 Aug;
182(3):559-72.
PMID: 18695046
Processing bodies (P bodies) are conserved mRNA-protein (mRNP) granules that are thought to be cytoplasmic centers for mRNA repression and degradation. However, their specific functions in vivo remain poorly understood....
6.
Huang F, Goh L, Sorkin A
Proc Natl Acad Sci U S A
. 2007 Oct;
104(43):16904-9.
PMID: 17940017
Ubiquitination of the EGF receptor (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and down-regulation. Mutation of EGFR ubiquitination sites identified by mass spectrometry yielded receptor mutants that...