Alexander Sorkin
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Explore the profile of Alexander Sorkin including associated specialties, affiliations and a list of published articles.
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95
Citations
5034
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Recent Articles
11.
Surve S, Watkins S, Sorkin A
J Cell Biol
. 2021 Sep;
220(11).
PMID: 34515735
The subcellular localization of RAS GTPases defines the operational compartment of the EGFR-ERK1/2 signaling pathway within cells. Hence, we used live-cell imaging to demonstrate that endogenous KRAS and NRAS tagged...
12.
Mourad M, Jacob T, Sadovsky E, Bejerano S, Salazar-De Simone G, Bagalkot T, et al.
Sci Rep
. 2021 Jul;
11(1):14390.
PMID: 34257394
The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental...
13.
Perez Verdaguer M, Zhang T, Paulo J, Gygi S, Watkins S, Sakurai H, et al.
J Cell Biol
. 2021 May;
220(7).
PMID: 34032851
Ligand binding triggers clathrin-mediated and, at high ligand concentrations, clathrin-independent endocytosis of EGFR. Clathrin-mediated endocytosis (CME) of EGFR is also induced by stimuli activating p38 MAPK. Mechanisms of both ligand-...
14.
Ouyang Y, Bagalkot T, Fitzgerald W, Sadovsky E, Chu T, Martinez-Marchal A, et al.
mSphere
. 2021 Apr;
6(2).
PMID: 33853873
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a massive impact on human lives worldwide. While the airborne SARS-CoV-2 primarily affects...
15.
Perez Verdaguer M, Larsen M, Bruchez M, Watkins S, Sorkin A
Bio Protoc
. 2021 Mar;
9(24):e3463.
PMID: 33654955
Functional activities of many transmembrane proteins are controlled by their endocytosis. One of the most studied experimental models is the epidermal growth factor (EGF) receptor (EGFR). However, endocytic trafficking of...
16.
Sorkina T, Cheng M, Bagalkot T, Wallace C, Watkins S, Bahar I, et al.
J Biol Chem
. 2021 Feb;
296:100430.
PMID: 33610553
Dopamine transporter (DAT) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. Mammalian DAT has been observed to form oligomers, although the...
17.
Von Zastrow M, Sorkin A
Annu Rev Biochem
. 2021 Feb;
90:709-737.
PMID: 33606955
Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40 years ago through the study of tyrosine kinase growth factor receptors, are now known to exist for multiple receptor...
18.
Bagalkot T, Block E, Bucchin K, Balcita-Pedicino J, Calderon M, Sesack S, et al.
J Neurosci
. 2020 Nov;
41(2):234-250.
PMID: 33234607
Dopamine transporter (DAT) controls dopamine neurotransmission by clearing synaptically released dopamine. However, trafficking itineraries of DAT, which determine its cell-surface concentration near synapses, are poorly characterized. It is especially unknown...
19.
Sadovsky Y, Ouyang Y, Powell J, Li H, Mouillet J, Morelli A, et al.
Placenta
. 2020 Nov;
102:34-38.
PMID: 33218576
The discovery of regulated trafficking of extracellular vesicles (EVs) has added a new dimension to our understanding of local and distant communication among cells and tissues. Notwithstanding the expanded landscape...
20.
Li H, Pinilla-Macua I, Ouyang Y, Sadovsky E, Kajiwara K, Sorkin A, et al.
J Extracell Vesicles
. 2020 Sep;
9(1):1812261.
PMID: 32944196
Pregnancy is a unique situation, in which placenta-derived small extracellular vesicles (sEVs) may communicate with maternal and foetal tissues. While relevant to homoeostatic and pathological functions, the mechanisms underlying sEV...