Alexander Solovyov
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Explore the profile of Alexander Solovyov including associated specialties, affiliations and a list of published articles.
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28
Citations
2211
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Recent Articles
1.
Solovyov A, Behr J, Hoyos D, Banks E, Drong A, Thornlow B, et al.
Nat Commun
. 2025 Feb;
16(1):2049.
PMID: 40021663
Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-genome sequencing (WGS) samples and...
2.
Puzio-Kuter A, Xu L, McBrayer M, Dominique R, Li H, Fahr B, et al.
Cancer Discov
. 2025 Feb;
PMID: 39945593
Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. Here, we describe rezatapopt (PC14586), part of a...
3.
Amisaki M, Zebboudj A, Yano H, Zhang S, Payne G, Chandra A, et al.
Nature
. 2025 Jan;
638(8052):1076-1084.
PMID: 39814891
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ...
4.
Ishak C, Marhon S, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga I, et al.
Cancer Discov
. 2025 Jan;
PMID: 39776167
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription...
5.
Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov K, et al.
Immunity
. 2024 Nov;
57(12):2879-2894.e11.
PMID: 39577413
To thrive, cancer cells must navigate acute inflammatory signaling accompanying oncogenic transformation, such as via overexpression of repeat elements. We examined the relationship between immunostimulatory repeat expression, tumor evolution, and...
6.
Sun S, Hong J, You E, Tsanov K, Chacon-Barahona J, Di Gioacchino A, et al.
bioRxiv
. 2023 Jun;
PMID: 37292765
Overexpression of repetitive elements is an emerging hallmark of human cancers . Diverse repeats can mimic viruses by replicating within the cancer genome through retrotransposition, or presenting pathogen-associated molecular patterns...
7.
Vabret N, Najburg V, Solovyov A, Gopal R, McClain C, Sulc P, et al.
iScience
. 2022 Jul;
25(7):104599.
PMID: 35789859
Pattern recognition receptors (PRRs) protect against microbial invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. Although microbial-derived PRR ligands have been extensively characterized, the...
8.
Porter R, Sun S, Flores M, Berzolla E, You E, Phillips I, et al.
J Clin Invest
. 2022 Jun;
132(16).
PMID: 35708912
Aberrant expression of viral-like repeat elements is a common feature of epithelial cancers, and the substantial diversity of repeat species provides a distinct view of the cancer transcriptome. Repeatome profiling...
9.
Lyudovyk O, Kim J, Qualls D, Hwee M, Lin Y, Boutemine S, et al.
Cancer Cell
. 2022 Jun;
40(7):738-753.e5.
PMID: 35679859
How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in 103 patients with prior COVID-19 infection, more than...
10.
Rajurkar M, Parikh A, Solovyov A, You E, Kulkarni A, Chu C, et al.
Cancer Discov
. 2022 Mar;
12(6):1462-1481.
PMID: 35320348
Significance: Colorectal cancers express abundant repeat elements that have a viral-like life cycle that can be therapeutically targeted with nucleoside reverse transcriptase inhibitors (NRTI) commonly used for viral diseases. NRTIs...