Benjamin D Greenbaum
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Explore the profile of Benjamin D Greenbaum including associated specialties, affiliations and a list of published articles.
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63
Citations
3256
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Recent Articles
1.
Solovyov A, Behr J, Hoyos D, Banks E, Drong A, Thornlow B, et al.
Nat Commun
. 2025 Feb;
16(1):2049.
PMID: 40021663
Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-genome sequencing (WGS) samples and...
2.
Sethna Z, Guasp P, Reiche C, Milighetti M, Ceglia N, Patterson E, et al.
Nature
. 2025 Feb;
PMID: 39972124
A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens may...
3.
Puzio-Kuter A, Xu L, McBrayer M, Dominique R, Li H, Fahr B, et al.
Cancer Discov
. 2025 Feb;
PMID: 39945593
Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. Here, we describe rezatapopt (PC14586), part of a...
4.
You E, Patel B, Rojas A, Sun S, Danaher P, Ho N, et al.
Cancer Discov
. 2025 Feb;
PMID: 39919290
Repeat element viral mimicry is a common feature in pancreatic ductal adenocarcinoma (PDAC) that require mechanisms to manage this repeat "viral" load and attenuate innate immune responses. Here, we show...
5.
Dikiy S, Ghelani A, Levine A, Martis S, Giovanelli P, Wang Z, et al.
Nat Immunol
. 2025 Feb;
26(3):444-458.
PMID: 39905200
Regulatory T (T) cells are a specialized CD4 T cell lineage with essential anti-inflammatory functions. Analysis of T cell adaptations to non-lymphoid tissues that enable their specialized immunosuppressive and tissue-supportive...
6.
Ishak C, Marhon S, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga I, et al.
Cancer Discov
. 2025 Jan;
PMID: 39776167
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription...
7.
Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov K, et al.
Immunity
. 2024 Nov;
57(12):2879-2894.e11.
PMID: 39577413
To thrive, cancer cells must navigate acute inflammatory signaling accompanying oncogenic transformation, such as via overexpression of repeat elements. We examined the relationship between immunostimulatory repeat expression, tumor evolution, and...
8.
Bozkus C, Brown M, Velazquez L, Thomas M, Wilson E, ODonnell T, et al.
bioRxiv
. 2024 Nov;
PMID: 39484455
As SARS-CoV-2 variants continue to emerge capable of evading neutralizing antibodies, it has become increasingly important to fully understand the breadth and functional profile of T cell responses to determine...
9.
You E, Danaher P, Lu C, Sun S, Zou L, Phillips I, et al.
Cell
. 2024 Oct;
187(25):7232-7247.e23.
PMID: 39383862
Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) mimics viral-like responses with implications on tumor cell state and the response of the surrounding microenvironment. To better understand the...
10.
Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le A, et al.
bioRxiv
. 2024 Apr;
PMID: 38617260
Pathogenic germline alterations cause Li-Fraumeni Syndrome (LFS), and breast cancer is the most common cancer in LFS females. We performed first of its kind multimodal analysis of LFS breast cancer...