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Alexander S Maltsev

Explore the profile of Alexander S Maltsev including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 550
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Recent Articles
1.
Ptak C, Hsieh C, Lin Y, Maltsev A, Raman R, Sharma Y, et al.
Biochemistry . 2014 Jul; 53(32):5249-60. PMID: 25068811
A number of surface proteins specific to pathogenic strains of Leptospira have been identified. The Lig protein family has shown promise as a marker in typing leptospiral isolates for pathogenesis...
2.
Mantsyzov A, Maltsev A, Ying J, Shen Y, Hummer G, Bax A
Protein Sci . 2014 Jul; 23(9):1275-90. PMID: 24976112
α-Synuclein is an intrinsically disordered protein of 140 residues that switches to an α-helical conformation upon binding phospholipid membranes. We characterize its residue-specific backbone structure in free solution with a...
3.
Maltsev A, Grishaev A, Roche J, Zasloff M, Bax A
J Am Chem Soc . 2014 Feb; 136(10):3752-5. PMID: 24568736
The antibiotic squalamine forms a lyotropic liquid crystal at very low concentrations in water (0.3-3.5% w/v), which remains stable over a wide range of temperature (1-40 °C) and pH (4-8)....
4.
Roche J, Ying J, Maltsev A, Bax A
Chembiochem . 2013 Jul; 14(14):1754-61. PMID: 23813793
The impact of pressure on the backbone (15) N, (1) H and (13) C chemical shifts in N-terminally acetylated α-synuclein has been evaluated over a pressure range 1-2500 bar. Even...
5.
Gruschus J, Yap T, Pistolesi S, Maltsev A, Lee J
Biochemistry . 2013 Apr; 52(20):3436-45. PMID: 23607618
Calmodulin (CaM) is a calcium binding protein that plays numerous roles in Ca-dependent cellular processes, including uptake and release of neurotransmitters in neurons. α-Synuclein (α-syn), one of the most abundant...
6.
Lorieau J, Maltsev A, Louis J, Bax A
J Biomol NMR . 2013 Mar; 55(4):369-77. PMID: 23508769
We demonstrate that alignment of a structured peptide or small protein solubilized in mixed phospholipid:detergent micelles or bicelles, when embedded in a compressed gel or liquid crystalline medium, can be...
7.
Maltsev A, Chen J, Levine R, Bax A
J Am Chem Soc . 2013 Feb; 135(8):2943-6. PMID: 23398174
α-Synuclein (αS) is an intrinsically disordered protein that is water-soluble but also can bind negatively charged lipid membranes while adopting an α-helical conformation. Membrane affinity is increased by post-translational N-terminal...
8.
Maltsev A, Ying J, Bax A
J Biomol NMR . 2012 Sep; 54(2):181-91. PMID: 22960996
Intrinsically disordered proteins (IDPs) are abundant in nature and characterization of their potential structural propensities remains a widely pursued but challenging task. Analysis of NMR secondary chemical shifts plays an...
9.
Maltsev A, Ying J, Bax A
Biochemistry . 2012 Jun; 51(25):5004-13. PMID: 22694188
N-Terminal acetylation of α-synuclein (aS), a protein implicated in the etiology of Parkinson's disease, is common in mammals. The impact of this modification on the protein's structure and dynamics in...
10.
Pfefferkorn C, Heinrich F, Sodt A, Maltsev A, Pastor R, Lee J
Biophys J . 2012 Feb; 102(3):613-21. PMID: 22325285
α-Synuclein (α-syn) membrane interactions are implicated in the pathogenesis of Parkinson's disease. Fluorescence and neutron reflectometry (NR) measurements reveal that α-syn penetrates ∼9-14 Å into the outer leaflet of the...