Michael Zasloff
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Explore the profile of Michael Zasloff including associated specialties, affiliations and a list of published articles.
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77
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6089
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Recent Articles
1.
Verheij V, Diecidue R, Botman E, Harrington J, Haga N, Hidalgo-Bravo A, et al.
Expert Opin Pharmacother
. 2025 Jan;
26(3):291-299.
PMID: 39834193
Introduction: Palovarotene is a retinoic acid receptor gamma agonist that was studied in phase-2 and phase-3 clinical trials for the inhibition of new heterotopic ossification (HO) in fibrodysplasia ossificans progressiva...
2.
Barbut D, Perni M, Zasloff M
NPJ Aging
. 2024 Dec;
10(1):62.
PMID: 39702521
The development of anti-aging drugs is challenged by both the apparent complexity of the physiological mechanisms involved in aging and the likelihood that many of these mechanisms remain unknown. As...
3.
Barbut D, Kinney W, Chen H, Stewart A, Hecksher-Sorensen J, Zhang C, et al.
Diabetes Obes Metab
. 2024 Sep;
26(12):5701-5712.
PMID: 39307948
ENT-03, a spermine bile acid we recently discovered in the brain of newborn mice acts centrally to regulate energy and metabolism. Obese, diabetic (ob/ob) mice treated with five doses of...
4.
Ashiqueali S, Schneider A, Zhu X, Juszczyk E, Mansoor M, Zhu Y, et al.
Aging Cell
. 2024 May;
23(9):e14227.
PMID: 38798180
Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing the course of postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall health....
5.
McVey Neufeld K, Mao Y, West C, Ahn M, Hameed H, Iwashita E, et al.
Commun Biol
. 2024 Jan;
7(1):80.
PMID: 38200107
Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse physiological processes that decline with age. Gut to brain vagus firing patterns are regulated by myenteric...
6.
Errico S, Lucchesi G, Odino D, Osman E, Cascella R, Neri L, et al.
J Med Chem
. 2023 Jul;
66(14):9519-9536.
PMID: 37433124
Natural aminosterols are promising drug candidates against neurodegenerative diseases, like Alzheimer and Parkinson, and one relevant protective mechanism occurs via their binding to biological membranes and displacement or binding inhibition...
7.
Barletti B, Lucchesi G, Muscat S, Errico S, Barbut D, Danani A, et al.
Colloids Surf B Biointerfaces
. 2023 Jan;
222:113115.
PMID: 36603410
Trodusquemine is an amphipathic aminosterol that has recently shown therapeutic benefit in neurodegenerative diseases altering the binding of misfolded proteins to the cell membrane. To unravel the underlying mechanism, we...
8.
Capitini C, Pesce L, Fani G, Mazzamuto G, Genovese M, Franceschini A, et al.
FASEB J
. 2022 Nov;
36(12):e22655.
PMID: 36421008
Trodusquemine is an aminosterol with a variety of biological and pharmacological functions, such as acting as an antimicrobial, stimulating body weight loss and interfering with the toxicity of proteins involved...
9.
Camilleri M, Subramanian T, Pagan F, Isaacson S, Gil R, Hauser R, et al.
Ann Intern Med
. 2022 Nov;
175(12):1666-1674.
PMID: 36343348
Background: Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved constipation in an open-label study in patients with...
10.
Girlanda R, Liggett J, Jayatilake M, Kroemer A, Guerra J, Hawksworth J, et al.
Biomedicines
. 2022 Sep;
10(9).
PMID: 36140180
We analyzed the fecal microbiome by deep sequencing of the 16S ribosomal genes and the metabolomic profiles of 43 intestinal transplant recipients to identify biomarkers of graft function. Stool samples...