Alexander R Loftis
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Explore the profile of Alexander R Loftis including associated specialties, affiliations and a list of published articles.
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8
Citations
109
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Recent Articles
1.
Loftis A, Zhang G, Backlund C, Quartararo A, Pishesha N, Hanna C, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34417313
When displayed on erythrocytes, peptides and proteins can drive antigen-specific immune tolerance. Here, we investigated a straightforward approach based on erythrocyte binding to promote antigen-specific tolerance to both peptides and...
2.
Dhanjee H, Saebi A, Buslov I, Loftis A, Buchwald S, Pentelute B
J Am Chem Soc
. 2020 Jul;
142(28):12548.
PMID: 32603593
No abstract available.
3.
Loftis A, Santos M, Truex N, Biancucci M, Satchell K, Pentelute B
Chembiochem
. 2020 May;
21(19):2772-2776.
PMID: 32369652
The nontoxic, anthrax protective antigen/lethal factor N-terminal domain (PA/LF ) complex is an effective platform for translocating proteins into the cytosol of cells. Mutant PA (mPA) was recently fused to...
4.
Dhanjee H, Saebi A, Buslov I, Loftis A, Buchwald S, Pentelute B
J Am Chem Soc
. 2020 May;
142(20):9124-9129.
PMID: 32364380
Few chemical methods exist for the covalent conjugation of two proteins. We report the preparation of site-specific protein-protein conjugates that arise from the sequential cross-coupling of cysteine residues on two...
5.
Lu Z, Paolella B, Truex N, Loftis A, Liao X, Rabideau A, et al.
ACS Chem Biol
. 2020 Apr;
15(6):1358-1369.
PMID: 32348107
Antisense oligonucleotide therapies are important cancer treatments, which can suppress genes in cancer cells that are critical for cell survival. has recently emerged as a promising gene target that encodes...
6.
Mandala V, Loftis A, Shcherbakov A, Pentelute B, Hong M
Nat Struct Mol Biol
. 2020 Feb;
27(2):160-167.
PMID: 32015551
The influenza B M2 (BM2) proton channel is activated by acidic pH to mediate virus uncoating. Unlike influenza A M2 (AM2), which conducts protons with strong inward rectification, BM2 conducts...
7.
Jack S, Madhivanan K, Ramadesikan S, Subramanian S, Edwards 2nd D, Elzey B, et al.
Int J Cancer
. 2019 Oct;
146(2):449-460.
PMID: 31584195
Bladder cancer is the sixth most common cancer in the United States, and it exhibits an alarming 70% recurrence rate. Thus, the development of more efficient antibladder cancer approaches is...
8.
Romano K, Warrier T, Poulsen B, Nguyen P, Loftis A, Saebi A, et al.
Antimicrob Agents Chemother
. 2019 Jun;
63(9).
PMID: 31235628
is a major bacterial pathogen associated with a rising prevalence of antibiotic resistance. We evaluated the resistance mechanisms of against POL7080, a species-specific, first-in-class antibiotic in clinical trials that targets...