Alexander N R Weber
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Explore the profile of Alexander N R Weber including associated specialties, affiliations and a list of published articles.
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78
Citations
2428
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Recent Articles
1.
Rudalska R, Harbig J, Forster M, Woelffing P, Esposito A, Kudolo M, et al.
Nat Cancer
. 2025 Jan;
6(2):259-277.
PMID: 39820127
Colorectal cancer (CRC) constitutes the second leading cause of cancer-related death worldwide and advanced CRCs are resistant to targeted therapies, chemotherapies and immunotherapies. p38α (Mapk14) has been suggested as a...
2.
Saller B, Wohrle S, Fischer L, Dufossez C, Ingerl I, Kessler S, et al.
Immunity
. 2024 Nov;
58(1):90-107.e11.
PMID: 39571574
How mitochondria reconcile roles in functionally divergent cell death pathways of apoptosis and NLRP3 inflammasome-mediated pyroptosis remains elusive, as is their precise role in NLRP3 activation and the evolutionarily conserved...
3.
Leal V, Bork F, Mateo Tortola M, von Guilleaume J, Greve C, Bugl S, et al.
J Allergy Clin Immunol
. 2024 Nov;
155(2):569-582.
PMID: 39547282
Background: Inflammation is a double-edged state of immune activation that is required to resolve threats harmful to the host, but can also cause severe collateral damage. Polymorphonuclear neutrophils (PMNs), the...
4.
Knopp T, Jung R, Wild J, Bochenek M, Efentakis P, Lehmann A, et al.
Eur Heart J Open
. 2024 Jul;
4(4):oeae046.
PMID: 39015379
Aims: The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well as cardiovascular disease progression. Since myeloid cells are a primary source of IL-6 formation, we...
5.
Bork F, Greve C, Youn C, Chen S, Leal V, Wang Y, et al.
EMBO Rep
. 2024 May;
25(7):2914-2949.
PMID: 38783164
Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs). NETs counteract microbes but are also linked to inflammation in atherosclerosis, arthritis,...
6.
Weber A, Mateo Tortola M, Kuemmerle-Deschner J
J Exp Med
. 2024 Mar;
221(5).
PMID: 38536100
Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome (CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome mutations, poses challenges. A novel classification approach may help inform therapeutic decisions and...
7.
Cardona Gloria Y, Weber A
Methods Mol Biol
. 2023 Aug;
2696:239-256.
PMID: 37578727
Interleukin (IL)-1β is a key mediator of inflammation and activates via pattern recognition receptors (PRR) of the inflammasome family by proteolytic maturation. Proteolysis is driven by proteases such as caspase-1...
8.
Maia A, Cardona Gloria Y, Fuchs K, Chang T, Engels P, Zhou M, et al.
J Leukoc Biol
. 2023 Apr;
114(2):180-186.
PMID: 37075217
Chitin is a highly abundant N-acetylglucosamine polysaccharide that has been linked to immune responses in the context of fungal infections and allergic asthma, especially to T helper 2 immune responses....
9.
Bhattacharya S, Maupin A, Schlosser A, Fuchtbauer E, Cardona Gloria Y, Weber A, et al.
PLoS One
. 2023 Mar;
18(3):e0282347.
PMID: 36888604
Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine...
10.
Bellut M, Bieber M, Kraft P, Weber A, Stoll G, Schuhmann M
J Neuroinflammation
. 2023 Jan;
20(1):4.
PMID: 36600259
Background: Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalization,...