Alexander Meissner
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Explore the profile of Alexander Meissner including associated specialties, affiliations and a list of published articles.
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193
Citations
32611
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Recent Articles
21.
Asimi V, Kumar A, Niskanen H, Riemenschneider C, Hetzel S, Naderi J, et al.
Nat Genet
. 2022 Jul;
54(8):1238-1247.
PMID: 35864192
Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality during early development has been a mystery. Here, we report that rapid...
22.
Bolondi A, Kretzmer H, Meissner A
Curr Opin Genet Dev
. 2022 Jul;
76:101947.
PMID: 35839561
The totipotent zygote gives rise to diverse cell types through a series of well-orchestrated regulatory mechanisms. Epigenetic modifiers play an essential, though still poorly understood, role in the transition from...
23.
Hetzel S, Mattei A, Kretzmer H, Qu C, Chen X, Fan Y, et al.
Nat Cancer
. 2022 May;
3(6):768-782.
PMID: 35590059
DNA methylation is tightly regulated during development and is stably maintained in healthy cells. In contrast, cancer cells are commonly characterized by a global loss of DNA methylation co-occurring with...
24.
Mattei A, Bailly N, Meissner A
Trends Genet
. 2022 May;
38(7):676-707.
PMID: 35504755
In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance was not intuitive for several decades. After this initial lag, the ubiquitous presence of this methylated base emerged...
25.
Pour M, Kumar A, Farag N, Bolondi A, Kretzmer H, Walther M, et al.
iScience
. 2022 Jan;
25(1):103556.
PMID: 34988400
The segregation of definitive endoderm (DE) from bipotent mesendoderm progenitors leads to the formation of two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs...
26.
Blanco M, Sykes D, Gu L, Wu M, Petroni R, Karnik R, et al.
Cell Rep
. 2021 Nov;
37(6):109967.
PMID: 34758323
Stem and progenitor cells have the capacity to balance self-renewal and differentiation. Hematopoietic myeloid progenitors replenish more than 25 billion terminally differentiated neutrophils every day under homeostatic conditions and can...
27.
Andergassen D, Smith Z, Kretzmer H, Rinn J, Meissner A
Dev Cell
. 2021 Nov;
56(21):2995-3005.e4.
PMID: 34752748
Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to encode allele-specific expression, but how these specific tasks are accomplished at single loci or across chromosomal scales remains incompletely...
28.
Biran A, Yin S, Kretzmer H, Ten Hacken E, Parvin S, Lucas F, et al.
Cancer Res
. 2021 Oct;
81(24):6117-6130.
PMID: 34686499
Chronic lymphocytic leukemia (CLL) is characterized by disordered DNA methylation, suggesting these epigenetic changes might play a critical role in disease onset and progression. The methyltransferase is a key regulator...
29.
RLM: fast and simplified extraction of read-level methylation metrics from bisulfite sequencing data
Hetzel S, Giesselmann P, Reinert K, Meissner A, Kretzmer H
Bioinformatics
. 2021 Oct;
37(21):3934-3935.
PMID: 34601556
Summary: Bisulfite sequencing data provide value beyond the straightforward methylation assessment by analyzing single-read patterns. Over the past years, various metrics have been established to explore this layer of information....
30.
Huang Y, Chen C, Sundaramurthy V, Slabicki M, Hao D, Watson C, et al.
Cancer Discov
. 2021 Aug;
12(1):220-235.
PMID: 34429321
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A () are the most common driver of this state....