Alexander Meissner
Overview
Explore the profile of Alexander Meissner including associated specialties, affiliations and a list of published articles.
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Articles
193
Citations
32611
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Recent Articles
11.
Klever M, Strang E, Hetzel S, Jungnitsch J, Dolnik A, Schopflin R, et al.
Blood Adv
. 2023 Aug;
7(21):6520-6531.
PMID: 37582288
Acute myeloid leukemia with complex karyotype (CK-AML) is associated with poor prognosis, which is only in part explained by underlying TP53 mutations. Especially in the presence of complex chromosomal rearrangements,...
12.
Hoetker M, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong L, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1121-1134.
PMID: 37460697
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities...
13.
Kumar A, Tian L, Bolondi A, Hernandez A, Stickels R, Kretzmer H, et al.
Nat Genet
. 2023 Jul;
55(7):1176-1185.
PMID: 37414952
Spatiotemporal orchestration of gene expression is required for proper embryonic development. The use of single-cell technologies has begun to provide improved resolution of early regulatory dynamics, including detailed molecular definitions...
14.
Guo H, Vuille J, Wittner B, Lachtara E, Hou Y, Lin M, et al.
Cell
. 2023 Jun;
186(13):2765-2782.e28.
PMID: 37327786
Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, whose contribution to tumorigenesis is uncertain. Through high-resolution genome-wide single-cell DNA methylation sequencing, we identify 40 core domains that are...
15.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik I, Yung P, et al.
Nat Cell Biol
. 2023 Apr;
25(4):579-591.
PMID: 37024684
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA...
16.
Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, et al.
Elife
. 2023 Jan;
12.
PMID: 36719724
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of...
17.
Stevens L, Peluffo G, Qiu X, Temko D, Fassl A, Li Z, et al.
Cancer Res
. 2022 Nov;
83(2):264-284.
PMID: 36409824
Significance: Chemotherapy resistance in inflammatory breast cancer is driven by the JAK2/STAT3 pathway, in part via cAMP/PKA signaling and a cell state switch, which can be overcome using paclitaxel combined...
18.
Ringel A, Szabo Q, Chiariello A, Chudzik K, Schopflin R, Rothe P, et al.
Cell
. 2022 Sep;
185(20):3689-3704.e21.
PMID: 36179666
Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental...
19.
Knisbacher B, Lin Z, Hahn C, Nadeu F, Duran-Ferrer M, Stevenson K, et al.
Nat Genet
. 2022 Aug;
54(11):1664-1674.
PMID: 35927489
Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymphocytic leukemia (CLL),...
20.
Yuan W, Ma S, Brown J, Kim K, Murek V, Trastulla L, et al.
Nat Neurosci
. 2022 Aug;
25(8):1049-1058.
PMID: 35915179
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. Cortical neurons are born during embryonic development, and their maturation extends into postnatal life. The...