Alexander Kondrashov
Overview
Explore the profile of Alexander Kondrashov including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
466
Followers
0
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Recent Articles
1.
Kwan Z, Paulose Nadappuram B, Leung M, Mohagaonkar S, Li A, Amaradasa K, et al.
Circ Res
. 2023 Oct;
133(11):944-958.
PMID: 37869877
Background: βAR (beta-1 adrenergic receptor) and βAR (beta-2 adrenergic receptor)-mediated cyclic adenosine monophosphate signaling has distinct effects on cardiac function and heart failure progression. However, the mechanism regulating spatial localization...
2.
Blythe M, Kocer A, Rubio-Roldan A, Giles T, Abakir A, Ialy-Radio C, et al.
Commun Biol
. 2021 Jun;
4(1):691.
PMID: 34099857
Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring...
3.
Kondrashov A
FEBS Open Bio
. 2021 Jun;
11(6):1520-1523.
PMID: 34060719
In this issue of FEBS Open Bio, Shen Li et al., in the laboratory of Hector L. Franco (University of North Carolina), provide a proof-of-principle solution for correcting all copies...
4.
Goulding J, Kondrashov A, Mistry S, Melarangi T, Vo N, Hoang D, et al.
FASEB J
. 2021 Mar;
35(4):e21398.
PMID: 33710675
The importance of cell phenotype in determining the molecular mechanisms underlying β -adrenoceptor (β2AR) function has been noted previously when comparing responses in primary cells and recombinant model cell lines....
5.
Kondrashov A, Mohd Yusof N, Hasan A, Goulding J, Kodagoda T, Hoang D, et al.
Mol Ther Methods Clin Dev
. 2020 Dec;
20:39-53.
PMID: 33335946
During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (βAR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic...
6.
Kondrashov A, Karpova E
Methods Mol Biol
. 2020 Aug;
2198:401-428.
PMID: 32822047
CRISPR/cas9 is a popular tool, widely used today for genome editing. However, the modular organization of this tool allows it to be used not only for DNA modifications but also...
7.
Kilpatrick L, Alcobia D, White C, Peach C, Glenn J, Zimmerman K, et al.
Cell Chem Biol
. 2019 Apr;
26(6):830-841.e9.
PMID: 30956148
Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma...
8.
Alcobia D, Ziegler A, Kondrashov A, Comeo E, Mistry S, Kellam B, et al.
iScience
. 2018 Sep;
6:280-288.
PMID: 30240618
The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than...
9.
Kondrashov A, Duc Hoang M, Smith J, Bhagwan J, Duncan G, Mosqueira D, et al.
Stem Cells Dev
. 2018 Feb;
27(6):391-404.
PMID: 29402189
Modeling disease with human pluripotent stem cells (hPSCs) is hindered because the impact on cell phenotype from genetic variability between individuals can be greater than from the pathogenic mutation. While...
10.
Denning C, Borgdorff V, Crutchley J, Firth K, George V, Kalra S, et al.
Biochim Biophys Acta
. 2015 Nov;
1863(7 Pt B):1728-48.
PMID: 26524115
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in...