Alexander J Federation
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Explore the profile of Alexander J Federation including associated specialties, affiliations and a list of published articles.
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10
Citations
613
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Recent Articles
1.
Heil L, Fondrie W, McGann C, Federation A, Noble W, MacCoss M, et al.
J Proteome Res
. 2022 May;
21(6):1382-1391.
PMID: 35549345
Advances in library-based methods for peptide detection from data-independent acquisition (DIA) mass spectrometry have made it possible to detect and quantify tens of thousands of peptides in a single mass...
2.
Federation A, Nandakumar V, Searle B, Stergachis A, Wang H, Pino L, et al.
Cell Rep
. 2020 Feb;
30(8):2463-2471.e5.
PMID: 32101728
Transcription factors and other chromatin-associated proteins are difficult to quantify comprehensively. Here, we combine facile nuclear sub-fractionation with data-independent acquisition mass spectrometry to achieve rapid, sensitive, and highly parallel quantification...
3.
Ott C, Federation A, Schwartz L, Kasar S, Klitgaard J, Lenci R, et al.
Cancer Cell
. 2018 Dec;
34(6):982-995.e7.
PMID: 30503705
Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define the core transcriptional regulatory circuits of normal and malignant cells. Gene control through enhancer activity is often dominated...
4.
Zhang Y, Federation A, Kim S, OKeefe J, Lun M, Xiang D, et al.
J Clin Invest
. 2018 Oct;
128(11):4898-4911.
PMID: 30277475
Adipocyte turnover in adulthood is low, suggesting that the cellular source of new adipocytes, the adipocyte progenitor (AP), resides in a state of relative quiescence. Yet the core transcriptional regulatory...
5.
Brown J, Feldman Z, Doherty S, Reyes J, Rahl P, Lin C, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(9):2144-2149.
PMID: 29444854
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression...
6.
Saint-Andre V, Federation A, Lin C, Abraham B, Reddy J, Lee T, et al.
Genome Res
. 2016 Feb;
26(3):385-96.
PMID: 26843070
A small set of core transcription factors (TFs) dominates control of the gene expression program in embryonic stem cells and other well-studied cellular models. These core TFs collectively regulate their...
7.
Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al.
Nature
. 2016 Jan;
530(7588):57-62.
PMID: 26814967
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour....
8.
Yi J, Federation A, Qi J, Dhe-Paganon S, Hadler M, Xu X, et al.
ACS Chem Biol
. 2014 Nov;
10(3):667-74.
PMID: 25397901
The DOT1L lysine methyltransferase has emerged as a validated therapeutic target in MLL-rearranged (MLLr) acute leukemias. Although S-adenosylmethionine competitive inhibitors have demonstrated pharmacological proof-of-principle in MLLr-leukemia, these compounds require further...
9.
Federation A, Bradner J, Meissner A
Trends Cell Biol
. 2013 Nov;
24(3):179-87.
PMID: 24183602
Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription...
10.
Bowerman C, Liyanage W, Federation A, Nilsson B
Biomacromolecules
. 2011 May;
12(7):2735-45.
PMID: 21568346
Peptide self-assembly leading to cross-β amyloid structures is a widely studied phenomenon because of its role in amyloid pathology and the exploitation of amyloid as a functional biomaterial. The self-assembly...