Alexander G McLennan
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Explore the profile of Alexander G McLennan including associated specialties, affiliations and a list of published articles.
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30
Citations
383
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Recent Articles
1.
Seafood label quality and mislabelling rates hamper consumer choices for sustainability in Australia
Cundy M, Santana-Garcon J, McLennan A, Ayad M, Bayer P, Cooper M, et al.
Sci Rep
. 2023 Aug;
13(1):10146.
PMID: 37537170
Seafood mislabelling and species substitution, compounded by a convoluted seafood supply chain with significant traceability challenges, hinder efforts towards more sustainable, responsible, and ethical fishing and business practices. We conducted...
2.
Ferguson F, McLennan A, Urbaniak M, Jones N, Copeland N
Front Mol Biosci
. 2020 Dec;
7:606807.
PMID: 33282915
Cellular homeostasis requires adaption to environmental stress. In response to various environmental and genotoxic stresses, all cells produce dinucleoside polyphosphates (NpNs), the best studied of which is diadenosine tetraphosphate (ApA)....
3.
Kramer S, McLennan A
Wiley Interdiscip Rev RNA
. 2018 Oct;
10(1):e1511.
PMID: 30345629
The 5' ends of most RNAs are chemically modified to enable protection from nucleases. In bacteria, this is often achieved by keeping the triphosphate terminus originating from transcriptional initiation, while...
4.
Abdelraheim S, Spiller D, McLennan A
Protein J
. 2017 Jul;
36(5):425-432.
PMID: 28755312
The mammalian NUDT13 protein possesses a sequence motif characteristic of the NADH pyrophosphohydrolase subfamily of Nudix hydrolases. Due to the persistent insolubility of the recombinant product expressed in Escherichia coli,...
5.
Marriott A, Vasieva O, Fang Y, Copeland N, McLennan A, Jones N
PLoS One
. 2016 May;
11(5):e0154674.
PMID: 27144453
Regulation of gene expression is one of several roles proposed for the stress-induced nucleotide diadenosine tetraphosphate (Ap4A). We have examined this directly by a comparative RNA-Seq analysis of KBM-7 chronic...
6.
Marriott A, Copeland N, Cunningham R, Wilkinson M, McLennan A, Jones N
DNA Repair (Amst)
. 2015 Jul;
33:90-100.
PMID: 26204256
The level of intracellular diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) increases several fold in mammalian cells treated with non-cytotoxic doses of interstrand DNA-crosslinking agents such as mitomycin C. It is also increased...
7.
McLennan A
Cell Mol Life Sci
. 2012 Nov;
70(3):373-85.
PMID: 23184251
Many members of the nudix hydrolase family exhibit considerable substrate multispecificity and ambiguity, which raises significant issues when assessing their functions in vivo and gives rise to errors in database...
8.
Winward L, Whitfield W, McLennan A, Safrany S
Int J Biochem Cell Biol
. 2010 Apr;
42(7):1174-81.
PMID: 20394834
Unlike mammalian cells, Drosophila melanogaster contains only a single member of the diphosphoinositol polyphosphate phosphohydrolase subfamily of the Nudix hydrolases, suggesting that functional specialisation has not occurred in this organism....
9.
McLennan A
J Exp Biol
. 2009 Mar;
212(Pt 6):785-9.
PMID: 19251993
Encysted embryos of the brine shrimp Artemia franciscana are able to survive prolonged periods of anoxia even when fully hydrated. During this time there is no metabolism, raising the question...
10.
Fisher D, McLennan A
Cancer Lett
. 2007 Nov;
259(2):186-91.
PMID: 18006149
The pro-apoptotic Fhit tumor suppressor protein binds and hydrolyses diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) in vitro. We have measured the level of both these nucleotides in Fhit-positive HEK293...