Alexander G Beristain
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Explore the profile of Alexander G Beristain including associated specialties, affiliations and a list of published articles.
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24
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745
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Recent Articles
1.
Telkar N, Hui D, Penaherrera M, Yuan V, Martinez V, Stewart G, et al.
Res Sq
. 2025 Feb;
PMID: 39989957
The human placenta is the composite of multiple cell types, each which contributes uniquely to placental function. Small non-coding RNAs (sncRNAs) are regulators of gene expression and can be cell-specific....
2.
Shannon M, McNeill G, Koksal B, Baltayeva J, Wachter J, Castellana B, et al.
Dev Cell
. 2024 Feb;
59(6):776-792.e11.
PMID: 38359834
Human trophoblast stem cells (hTSCs) and related trophoblast organoids are state-of-the-art culture systems that facilitate the study of trophoblast development and human placentation. Using single-cell transcriptomics, we evaluate how organoids...
3.
Khan A, Inkster A, Penaherrera M, King S, Kildea S, Oberlander T, et al.
Res Sq
. 2023 Jul;
PMID: 37461679
: Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used to explore the connections between exposures, placental pathology, and fetal development. However,...
4.
Haider S, Beristain A
Hum Reprod
. 2023 Apr;
38(8):1449-1463.
PMID: 37119533
Research focused on human reproductive biology has primarily relied upon clinical samples affording mainly descriptive studies with limited implementation of functional or mechanistic understanding. More importantly, restricted access to human...
5.
Sharlandjieva V, Beristain A, Terry J
Front Med (Lausanne)
. 2023 Feb;
10:1096262.
PMID: 36744135
Introduction: Bacteria derived from the maternal circulation have been suggested to seed the human placenta during development leading to an intrinsic placental microbiome. This concept has become controversial as numerous...
6.
Wachter J, Shannon M, Beristain A
Gene Expr Patterns
. 2022 Oct;
46:119283.
PMID: 36307023
The metzincin family of metalloproteases coordinates tissue developmental processes through regulation of growth factor availability, receptor signaling, and cell-cell/cell-matrix adhesion. While roles for select metzincins in controlling trophoblast functions in...
7.
Shannon M, Baltayeva J, Castellana B, Wachter J, McNeill G, Yoon J, et al.
Development
. 2022 Jan;
149(1).
PMID: 35020896
In early placental development, progenitor cytotrophoblasts (CTB) differentiate along one of two cellular trajectories: the villous or extravillous pathways. CTB committed to the villous pathway fuse with neighboring CTB to...
8.
Yuan V, Hui D, Yin Y, Penaherrera M, Beristain A, Robinson W
BMC Genomics
. 2021 Jan;
22(1):6.
PMID: 33407091
Background: DNA methylation (DNAm) profiling has emerged as a powerful tool for characterizing the placental methylome. However, previous studies have focused primarily on whole placental tissue, which is a mixture...
9.
Majali-Martinez A, Hoch D, Tam-Amersdorfer C, Pollheimer J, Glasner A, Ghaffari-Tabrizi-Wizsy N, et al.
FASEB J
. 2020 Jul;
34(8):10720-10730.
PMID: 32614494
Adequate anchoring of the placenta in the uterus through invasion of first trimester cytotrophoblasts (CTB) is required for a successful pregnancy. This process is mediated by matrix metalloproteinases (MMPs) and...
10.
St-Germain L, Castellana B, Baltayeva J, Beristain A
Int J Mol Sci
. 2020 May;
21(11).
PMID: 32471078
Inflammation is often equated to the physiological response to injury or infection. Inflammatory responses defined by cytokine storms control cellular mechanisms that can either resolve quickly (i.e., acute inflammation) or...