Alexander D Klose
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Explore the profile of Alexander D Klose including associated specialties, affiliations and a list of published articles.
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21
Citations
338
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Recent Articles
1.
Carossino M, Kenney D, OConnell A, Montanaro P, Tseng A, Gertje H, et al.
Viruses
. 2022 Mar;
14(3).
PMID: 35336942
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a...
2.
Allali A, Klose A, Berube-Lauziere Y
Biomed Opt Express
. 2021 Apr;
12(3):1422-1436.
PMID: 33796363
An efficient approach is introduced for modelling light propagation in the time domain in 3D heterogeneous absorbing and scattering media ( biological tissues) with curved boundaries. It relies on the...
3.
Carossino M, Montanaro P, OConnell A, Kenney D, Gertje H, Grosz K, et al.
bioRxiv
. 2021 Jan;
PMID: 33469581
Animal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter...
4.
Deng Z, Xu X, Dehghani H, Reyes J, Zheng L, Klose A, et al.
Proc SPIE Int Soc Opt Eng
. 2020 Nov;
11224.
PMID: 33223595
Genetically engineered mouse model(GEMM) that develops pancreatic ductal adenocarcinoma(PDAC) offers an experimental system to advance our understanding of radiotherapy(RT) for pancreatic cancer. Cone beam CT(CBCT)-guided small animal radiation research platform(SARRP)...
5.
Miyazaki T, Gharib S, Hsu Y, Xu K, Khodakivskyi P, Kobayashi A, et al.
Commun Biol
. 2019 Sep;
2:326.
PMID: 31508501
The kidney's inherent complexity has made identifying cell-specific pathways challenging, particularly when temporally associating them with the dynamic pathophysiology of acute kidney injury (AKI). Here, we combine renal cell-specific luciferase...
6.
Klose A, Paragas N
Nat Commun
. 2018 Oct;
9(1):4262.
PMID: 30323260
We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of...
7.
Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Deng R, et al.
J Clin Invest
. 2014 Jun;
124(7):2963-76.
PMID: 24937428
α-Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the...
8.
Klose A, Poschinger T
Phys Med Biol
. 2011 Feb;
56(5):1443-69.
PMID: 21321388
Fluorescence tomography (FT) reconstructs the three-dimensional (3D) fluorescent reporter probe distribution inside biological tissue. These probes target molecules of biological function, e.g. cell surface receptors or enzymes, and emit fluorescence...
9.
Montejo L, Klose A, Hielscher A
Biomed Opt Express
. 2011 Jan;
1(3):861-878.
PMID: 21258514
We present the first algorithm for solving the equation of radiative transfer (ERT) in the frequency domain (FD) on three-dimensional block-structured Cartesian grids (BSG). This algorithm allows for accurate modeling...
10.
Klose C, Klose A, Netz U, Scheel A, Beuthan J, Hielscher A
J Biomed Opt
. 2011 Jan;
15(6):066020.
PMID: 21198194
A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) in human finger joints using optical tomographic images. The image interpretation method employs a classification algorithm that makes use...