Alexander Cumberworth
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Explore the profile of Alexander Cumberworth including associated specialties, affiliations and a list of published articles.
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7
Citations
171
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Recent Articles
1.
Cumberworth A, Reinhardt A
Chem Soc Rev
. 2025 Jan;
54(5):2344-2368.
PMID: 39878142
DNA is not only a centrally important molecule in biology: the specificity of bonding that allows it to be the primary information storage medium for life has also allowed it...
2.
Cumberworth A, Wolde P
Phys Rev Lett
. 2023 Aug;
131(3):038401.
PMID: 37540881
In many organisms, cell division is driven by the constriction of a cytokinetic ring, which consists of actin filaments and crosslinking proteins. While it has long been believed that the...
3.
Niederauer C, Nguyen C, Wang-Henderson M, Stein J, Strauss S, Cumberworth A, et al.
Nat Commun
. 2023 Jul;
14(1):4345.
PMID: 37468504
DNA-PAINT based single-particle tracking (DNA-PAINT-SPT) has recently significantly enhanced observation times in in vitro SPT experiments by overcoming the constraints of fluorophore photobleaching. However, with the reported implementation, only a...
4.
Cumberworth A, Frenkel D, Reinhardt A
Nano Lett
. 2022 Aug;
22(17):6916-6922.
PMID: 36037484
Nucleation is the rate-determining step in the kinetics of many self-assembly processes. However, the importance of nucleation in the kinetics of DNA-origami self-assembly, which involves both the binding of staple...
5.
Cumberworth A, Reinhardt A, Frenkel D
J Chem Phys
. 2018 Dec;
149(23):234905.
PMID: 30579289
The optimal design of DNA origami systems that assemble rapidly and robustly is hampered by the lack of a model for self-assembly that is sufficiently detailed yet computationally tractable. Here,...
6.
Cumberworth A, Bui J, Gsponer J
J Comput Chem
. 2015 Nov;
37(7):629-40.
PMID: 26558440
Implicit solvent models for biomolecular simulations have been developed to use in place of more expensive explicit models; however, these models make many assumptions and approximations that are likely to...
7.
Cumberworth A, Lamour G, Babu M, Gsponer J
Biochem J
. 2013 Aug;
454(3):361-9.
PMID: 23988124
Because of their pervasiveness in eukaryotic genomes and their unique properties, understanding the role that ID (intrinsically disordered) regions in proteins play in the interactome is essential for gaining a...
8.
Trudeau T, Nassar R, Cumberworth A, Wong E, Woollard G, Gsponer J
Structure
. 2013 Feb;
21(3):332-41.
PMID: 23375259
Autoinhibition plays a significant role in the regulation of many proteins. By analyzing autoinhibited proteins, we demonstrate that these proteins are enriched in intrinsic disorder because of the properties of...