Jorg Gsponer
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Explore the profile of Jorg Gsponer including associated specialties, affiliations and a list of published articles.
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64
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2069
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Recent Articles
1.
Massah S, Pinette N, Foo J, Datta S, Guo M, Bell R, et al.
bioRxiv
. 2025 Jan;
PMID: 39868336
Highlights: AR-V7 condensates form independently of both androgens and AR-FL in CRPC models.AR-V7 mediates condensate-dependent and independent transcriptionCondensate-dependent transcription enables boosted expression of oncogenic KRAS genesCondensate-dependent genes exhibit an exponential...
2.
Cheung Y, Nam S, Fairlie G, Scheu K, Bui J, Shariati H, et al.
Autophagy
. 2025 Jan;
1-19.
PMID: 39809444
The multi-step macroautophagy/autophagy process ends with the cargo-laden autophagosome fusing with the lysosome to deliver the materials to be degraded. The metazoan-specific autophagy factor EPG5 plays a crucial role in...
3.
Malhis N, Gsponer J
Methods Mol Biol
. 2024 Nov;
2867:233-245.
PMID: 39576585
Intrinsically disordered protein regions, IDRs, are observed in many eukaryotic proteins. They play critical roles in essentially all cellular processes because segments of these regions, known as linear interacting peptides...
4.
Omidi A, Moller M, Malhis N, Bui J, Gsponer J
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2406407121.
PMID: 39446390
Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable challenges in structural characterization. IDRs are highly versatile, capable of adopting diverse structures and engagement modes. Motivated by recent strides...
5.
Cho D, Lee H, Kim J, Song J, Hwang S, Lee B, et al.
Database (Oxford)
. 2024 Aug;
2024.
PMID: 39192607
Autoinhibition, a crucial allosteric self-regulation mechanism in cell signaling, ensures signal propagation exclusively in the presence of specific molecular inputs. The heightened focus on autoinhibited proteins stems from their implication...
6.
Holguin-Cruz J, Bui J, Jha A, Na D, Gsponer J
Cell Syst
. 2024 Feb;
15(3):246-263.e7.
PMID: 38366601
Autoinhibition is a prevalent allosteric regulatory mechanism in signaling proteins. Reduced autoinhibition underlies the tumorigenic effect of some known cancer drivers, but whether autoinhibition is altered generally in cancer remains...
7.
Na D, Lim D, Hong J, Lee H, Cho D, Yu M, et al.
Mol Syst Biol
. 2023 Nov;
19(12):e11801.
PMID: 37984409
The accumulation of misfolded and aggregated proteins is a hallmark of neurodegenerative proteinopathies. Although multiple genetic loci have been associated with specific neurodegenerative diseases (NDs), molecular mechanisms that may have...
8.
Basu S, Zhao B, Biro B, Faraggi E, Gsponer J, Hu G, et al.
Nucleic Acids Res
. 2023 Nov;
52(D1):D426-D433.
PMID: 37933852
The DescribePROT database of amino acid-level descriptors of protein structures and functions was substantially expanded since its release in 2020. This expansion includes substantial increase in the size, scope, and...
9.
Molzahn C, Kuechler E, Zemlyankina I, Nierves L, Ali T, Cole G, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(45):e2310057120.
PMID: 37906643
During aging, the cellular response to unfolded proteins is believed to decline, resulting in diminished proteostasis. In model organisms, such as proteostatic decline with age has been linked to proteome...
10.
Kurgan L, Hu G, Wang K, Ghadermarzi S, Zhao B, Malhis N, et al.
Nat Protoc
. 2023 Sep;
18(11):3157-3172.
PMID: 37740110
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using computational predictions from primary structures, complements secondary and tertiary structure-based approaches. In this Tutorial, we...