Alexander Aulehla
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Explore the profile of Alexander Aulehla including associated specialties, affiliations and a list of published articles.
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23
Citations
1111
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Recent Articles
1.
Ho C, Jutras-Dube L, Zhao M, Monke G, Kiss I, Francois P, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(36):e2401604121.
PMID: 39190346
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts, e.g., chemical wave patterns, superconductors, and the unison applause we witness in concert halls. The existence...
2.
Seleit A, Brettell I, Fitzgerald T, Vibe C, Loosli F, Wittbrodt J, et al.
EMBO J
. 2024 Aug;
43(18):4068-4091.
PMID: 39122924
How the timing of development is linked to organismal size is a longstanding question. Although numerous studies have reported a correlation of temporal and spatial traits, the developmental or selective...
3.
Miyazawa H, Snaebjornsson M, Prior N, Kafkia E, Hammaren H, Tsuchida-Straeten N, et al.
Elife
. 2022 Dec;
11.
PMID: 36469462
How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here, we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model....
4.
Sanchez P, Mochulska V, Mauffette Denis C, Monke G, Tomita T, Tsuchida-Straeten N, et al.
Elife
. 2022 Oct;
11.
PMID: 36223168
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a...
5.
Falk H, Tomita T, Monke G, McDole K, Aulehla A
Development
. 2022 Jun;
149(13).
PMID: 35686648
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations...
6.
Seleit A, Aulehla A, Paix A
Elife
. 2021 Dec;
10.
PMID: 34870593
The CRISPR/Cas9 system has been used to generate fluorescently labelled fusion proteins by homology-directed repair in a variety of species. Despite its revolutionary success, there remains an urgent need for...
7.
Cable J, Pourquie O, Wellen K, Finley L, Aulehla A, Gould A, et al.
Ann N Y Acad Sci
. 2021 Aug;
1506(1):55-73.
PMID: 34414571
There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused...
8.
Miyazawa H, Aulehla A
Development
. 2018 Oct;
145(19).
PMID: 30275240
An emerging view emphasizes that metabolism is highly regulated in both time and space. In addition, it is increasingly being recognized that metabolic pathways are tightly connected to specific biological...
9.
Sonnen K, Lauschke V, Uraji J, Falk H, Petersen Y, Funk M, et al.
Cell
. 2018 Feb;
172(5):1079-1090.e12.
PMID: 29474908
How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM). In mouse embryos, this molecular...
10.
Bulusu V, Prior N, Snaebjornsson M, Kuehne A, Sonnen K, Kress J, et al.
Dev Cell
. 2017 Mar;
40(4):331-341.e4.
PMID: 28245920
How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we...