Alexander Agrotis
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Explore the profile of Alexander Agrotis including associated specialties, affiliations and a list of published articles.
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11
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1396
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Recent Articles
1.
Papandreou A, Singh N, Gianfrancesco L, Budinger D, Barwick K, Agrotis A, et al.
bioRxiv
. 2023 Sep;
PMID: 37745522
Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms of Neurodegeneration with Brain Iron Accumulation, caused by mutations in the gene encoding the autophagy-related protein, WDR45. The mechanisms linking...
2.
Agrotis A, Lamoliatte F, Williams T, Black A, Horberry R, Rousseau A
Life Sci Alliance
. 2023 Jan;
6(4).
PMID: 36693698
The homohexameric p97 complex, composed of Cdc48 subunits in yeast, is a crucial component of protein quality control pathways including ER-associated degradation. The complex acts to segregate protein complexes in...
3.
Williams T, Cacioppo R, Agrotis A, Black A, Zhou H, Rousseau A
Nat Cell Biol
. 2022 Jun;
24(7):1077-1087.
PMID: 35739319
When cells are stressed, bulk translation is often downregulated to reduce energy demands while stress-response proteins are simultaneously upregulated. To promote proteasome assembly and activity and maintain cell viability upon...
4.
Lee D, Cardinale D, Nigro E, Butler C, Rutman A, Fassad M, et al.
Eur Respir J
. 2021 Apr;
58(4).
PMID: 33795320
Background: Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is...
5.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
6.
Agrotis A, Ketteler R
Cells
. 2019 Dec;
9(1).
PMID: 31878323
Autophagy is an evolutionary conserved stress survival pathway that has been shown to play an important role in the initiation, progression, and metastasis of multiple cancers; however, little progress has...
7.
Agrotis A, von Chamier L, Oliver H, Kiso K, Singh T, Ketteler R
J Biol Chem
. 2019 Jul;
294(34):12610-12621.
PMID: 31315929
Microtubule-associated protein 1 light chain 3 α (LC3)/GABA type A receptor-associated protein (GABARAP) comprises a family of ubiquitin-like proteins involved in (macro)autophagy, an important intracellular degradation pathway that delivers cytoplasmic...
8.
Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells
Agrotis A, Pengo N, Burden J, Ketteler R
Autophagy
. 2019 Jan;
15(6):976-997.
PMID: 30661429
Macroautophagy/autophagy is a cellular degradation pathway that delivers cytoplasmic material to lysosomes via double-membrane organelles called autophagosomes. Lipidation of ubiquitin-like LC3/GABARAP proteins on the autophagosome membrane is important for autophagy....
9.
Pengo N, Prak K, Costa J, Luft C, Agrotis A, Freeman J, et al.
Front Cell Dev Biol
. 2018 Nov;
6:148.
PMID: 30443548
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated...
10.
Agrotis A, Ketteler R
Front Genet
. 2015 Oct;
6:300.
PMID: 26442115
CRISPR technology has rapidly changed the face of biological research, such that precise genome editing has now become routine for many labs within several years of its initial development. What...