Alexander A Perakis
Overview
Explore the profile of Alexander A Perakis including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
157
Followers
0
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Recent Articles
1.
Alatrash G, Qiao N, Zhang M, Zope M, Perakis A, Sukhumalchandra P, et al.
Clin Cancer Res
. 2019 Jan;
25(8):2610-2620.
PMID: 30647079
Purpose: Inefficient homing of adoptively transferred cytotoxic T lymphocytes (CTLs) to tumors is a major limitation to the efficacy of adoptive cellular therapy (ACT) for cancer. However, through fucosylation, a...
2.
Alatrash G, Perakis A, Kerros C, Peters H, Sukhumalchandra P, Zhang M, et al.
Clin Cancer Res
. 2018 Apr;
24(14):3386-3396.
PMID: 29661776
PR1 is a human leukocyte antigen (HLA)-A2 nonameric peptide derived from neutrophil elastase (NE) and proteinase 3 (P3). We have previously shown that PR1 is cross-presented by solid tumors, leukemia,...
3.
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target
Khan M, Carmona S, Sukhumalchandra P, Roszik J, Philips A, Perakis A, et al.
Front Immunol
. 2018 Feb;
8:1975.
PMID: 29422892
Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. We previously identified CG1 (FLLPTGAEA), a human...
4.
Gall V, Philips A, Qiao N, Clise-Dwyer K, Perakis A, Zhang M, et al.
Cancer Res
. 2017 Aug;
77(19):5374-5383.
PMID: 28819024
Early-phase clinical trials evaluating CD8 T cell-eliciting, HER2-derived peptide vaccines administered to HER2 breast cancer patients in the adjuvant setting suggest synergy between the vaccines and trastuzumab, the mAb targeting...
5.
Kerros C, Tripathi S, Zha D, Mehrens J, Sergeeva A, Philips A, et al.
J Biol Chem
. 2017 May;
292(24):10295-10305.
PMID: 28468826
Neutrophil elastase (NE) can be rapidly taken up by tumor cells that lack endogenous NE expression, including breast cancer, which results in cross-presentation of PR1, an NE-derived HLA-A2-restricted peptide that...
6.
Alatrash G, Garber H, Zhang M, Sukhumalchandra P, Qiu Y, Jakher H, et al.
Leukemia
. 2016 Aug;
31(1):234-237.
PMID: 27573556
No abstract available.