Alexander A Parent
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Explore the profile of Alexander A Parent including associated specialties, affiliations and a list of published articles.
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7
Citations
206
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Recent Articles
1.
Pollock J, Wardell S, Parent A, Stagg D, Ellison S, Alley H, et al.
Nat Chem Biol
. 2016 Aug;
12(10):795-801.
PMID: 27501397
Clinical resistance to the second-generation antiandrogen enzalutamide in castration-resistant prostate cancer (CRPC), despite persistent androgen receptor (AR) activity in tumors, highlights an unmet medical need for next-generation antagonists. We have...
2.
π-π interaction energies as determinants of the photodimerization of mono-, di-, and triazastilbenes
Parent A, Ess D, Katzenellenbogen J
J Org Chem
. 2014 May;
79(12):5448-62.
PMID: 24837276
We describe the quantitative [2 + 2] photocycloaddition of crystalline trans-2,4-dichloro-6-styrylpyrimidine to produce the corresponding htt r-ctt cyclobutane dimer, and we present (1)H NMR analysis of the photolysis of this...
3.
Nwachukwu J, Srinivasan S, Bruno N, Parent A, Hughes T, Pollock J, et al.
Elife
. 2014 Apr;
3:e02057.
PMID: 24771768
Resveratrol has beneficial effects on aging, inflammation and metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated protein kinase....
4.
Bruning J, Parent A, Gil G, Zhao M, Nowak J, Pace M, et al.
Nat Chem Biol
. 2010 Oct;
6(11):837-43.
PMID: 20924370
Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true: the conformational state...
5.
Gunther J, Parent A, Katzenellenbogen J
ACS Chem Biol
. 2009 May;
4(6):435-40.
PMID: 19441848
Compounds that directly disrupt the androgen receptor/steroid receptor coactivator interaction could function as novel inhibitors of androgen signaling that would remain effective in the treatment of prostate cancer that is...
6.
Parent A, Gunther J, Katzenellenbogen J
J Med Chem
. 2008 Sep;
51(20):6512-30.
PMID: 18785725
As an alternative approach to blocking estrogen action, we have developed small molecules that directly disrupt the key estrogen receptor (ER)/coactivator interaction necessary for gene activation. The more direct, protein-protein...
7.
Fleming S, Parent A, Parent E, Pincock J, Renault L
J Org Chem
. 2007 Nov;
72(25):9464-70.
PMID: 17997569
The photochemistry of substituted cinnamyloxy silanes has been examined in both cyclohexane and acetonitrile solvents. Alkene isomerization occurs in addition to cycloaddition. Fluorescence quantum yields and excited singlet state lifetimes...