Jerome C Nwachukwu
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Explore the profile of Jerome C Nwachukwu including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Tinivella A, Nwachukwu J, Pinzi L, Dettori M, Fabbri D, Carta P, et al.
J Nat Prod
. 2024 Nov;
87(11):2568-2579.
PMID: 39526345
In this work, we describe the results of a computational investigation aimed at identifying potential biological targets of honokiol, magnolol and a series of synthetic prodrug derivatives obtained through esterification...
2.
Angle S, Sharma H, Choi C, Carlson K, Hou Y, Nwachukwu J, et al.
J Am Chem Soc
. 2024 Oct;
146(45):30771-30777.
PMID: 39481083
We report the development of an iterative Matteson homologation reaction with catalyst-controlled diastereoselectivity through the design of a new catalyst. This reaction was applied to the selective synthesis of each...
3.
Min C, Nwachukwu J, Hou Y, Russo R, Papa A, Min J, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(24):e2321344121.
PMID: 38830107
The estrogen receptor-α (ER) is thought to function only as a homodimer but responds to a variety of environmental, metazoan, and therapeutic estrogens at subsaturating doses, supporting binding mixtures of...
4.
Min C, Nwachukwu J, Hou Y, Russo R, Papa A, Min J, et al.
bioRxiv
. 2024 Apr;
PMID: 38645081
Significance: The estrogen receptor-α (ER) regulates transcription in response to a hormonal milieu that includes low levels of estradiol, a variety of environmental estrogens, as well as ER antagonists such...
5.
Tinivella A, Nwachukwu J, Angeli A, Foschi F, Benatti A, Pinzi L, et al.
Eur J Med Chem
. 2022 Dec;
246:115011.
PMID: 36516582
Multi-target compounds have become increasingly important for the development of safer and more effective drug candidates. In this work, we devised a combined ligand-based and structure-based multi-target repurposing strategy and...
6.
Solis O, Beccari A, Iaconis D, Talarico C, Ruiz-Bedoya C, Nwachukwu J, et al.
Sci Adv
. 2022 Nov;
8(48):eadd4150.
PMID: 36449624
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme 2 as its primary infection mechanism. Interactions between S and endogenous proteins occur after infection but...
7.
Solis O, Beccari A, Iaconis D, Talarico C, Ruiz-Bedoya C, Nwachukwu J, et al.
bioRxiv
. 2022 Jun;
PMID: 35665018
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme 2 (ACE2) at the cell surface, which constitutes the primary mechanism driving SARS-CoV-2 infection. Molecular interactions...
8.
Bruno N, Nwachukwu J, Hughes D, Srinivasan S, Hawkins R, Sturgill D, et al.
FASEB J
. 2021 Nov;
35(12):e21999.
PMID: 34748223
The Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators drive Creb1-mediated transcription effects on metabolism in many tissues, but the in vivo effects of Crtc2/Creb1 transcription on skeletal muscle metabolism...
9.
Min J, Nwachukwu J, Min C, Njeri J, Srinivasan S, Rangarajan E, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(35).
PMID: 34452998
Efforts to improve estrogen receptor-α (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward...
10.
Bruno N, Nwachukwu J, Srinivasan S, Nettles C, Izard T, Jin Z, et al.
Nat Chem Biol
. 2021 Jan;
17(3):307-316.
PMID: 33510451
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target adverse effects including insulin resistance and skeletal muscle atrophy. We used a chemical systems biology approach, ligand class...