Alex J Vecchio
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Explore the profile of Alex J Vecchio including associated specialties, affiliations and a list of published articles.
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22
Citations
410
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Recent Articles
1.
Pacesa M, Nickel L, Schellhaas C, Schmidt J, Pyatova E, Kissling L, et al.
bioRxiv
. 2024 Dec;
PMID: 39677777
Protein-protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an...
2.
Ogbu C, Mandriota A, Liu X, de Las Alas M, Kapoor S, Choudhury J, et al.
bioRxiv
. 2024 Nov;
PMID: 39605593
Claudins are a 27-member protein family that form and fortify specialized cell contacts in endothelium and epithelium called tight junctions. Tight junctions restrict paracellular transport across tissues by forming molecular...
3.
Rathnayake S, Erramilli S, Kossiakoff A, Vecchio A
Structure
. 2024 Oct;
32(11):1936-1951.e5.
PMID: 39383874
Clostridium perfringens enterotoxin (CpE) causes prevalent and deadly gastrointestinal disorders. CpE binds to receptors called claudins on the apical surfaces of small intestinal epithelium. Claudins normally regulate paracellular transport but...
4.
Rathnayake S, Erramilli S, Kossiakoff A, Vecchio A
bioRxiv
. 2024 Jul;
PMID: 39026804
Pathogenic strains of Clostridium perfringens secrete an enterotoxin (CpE) that causes prevalent, severe, and sometimes deadly gastrointestinal disorders in humans and domesticated animals. CpE binds selectively to membrane protein receptors...
5.
Goverde C, Pacesa M, Goldbach N, Dornfeld L, Balbi P, Georgeon S, et al.
Nature
. 2024 Jun;
631(8020):449-458.
PMID: 38898281
De novo design of complex protein folds using solely computational means remains a substantial challenge. Here we use a robust deep learning pipeline to design complex folds and soluble analogues...
6.
Erramilli S, Dominik P, Ogbu C, Kossiakoff A, Vecchio A
Commun Biol
. 2024 Jun;
7(1):733.
PMID: 38886509
Claudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells. As the...
7.
Goverde C, Pacesa M, Goldbach N, Dornfeld L, Balbi P, Georgeon S, et al.
bioRxiv
. 2024 Mar;
PMID: 38496615
design of complex protein folds using solely computational means remains a significant challenge. Here, we use a robust deep learning pipeline to design complex folds and soluble analogues of integral...
8.
Ogbu C, Kapoor S, Vecchio A
Toxins (Basel)
. 2023 Nov;
15(11).
PMID: 37999500
Clostridium perfringens enterotoxin (CpE) is a β-pore forming toxin that disrupts gastrointestinal homeostasis in mammals by binding membrane protein receptors called claudins. Although structures of CpE fragments bound to claudins...
9.
Primeaux M, Liu X, Gowrikumar S, Fatima I, Fisher K, Bastola D, et al.
Cancer Lett
. 2023 Nov;
579:216479.
PMID: 37924938
Therapy resistance is the primary problem in treating late-stage colorectal cancer (CRC). Claudins are frequently dysregulated in cancer, and several are being investigated as novel therapeutic targets and biomarkers. We...
10.
Erramilli S, Dominik P, Ogbu C, Kossiakoff A, Vecchio A
bioRxiv
. 2023 Jul;
PMID: 37398044
Claudins are a family of ∼25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells. Humans have 27...