Alex G Therien
Overview
Explore the profile of Alex G Therien including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
896
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0
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Recent Articles
1.
Dong S, Zhao Z, Tang H, Li G, Pan J, Gu X, et al.
J Med Chem
. 2024 Feb;
67(5):3400-3418.
PMID: 38387069
The use of β-lactam (BL) and β-lactamase inhibitor combination to overcome BL antibiotic resistance has been validated through clinically approved drug products. However, unmet medical needs still exist for the...
2.
Kasper S, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, et al.
Bioeng Transl Med
. 2023 Sep;
8(5):e10542.
PMID: 37693049
Cyclic peptides are poised to target historically difficult to drug intracellular protein-protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have enabled...
3.
St-Onge M, Chefson A, Wu J, Caron-Duval E, Dumais V, Dorich S, et al.
Bioorg Med Chem Lett
. 2023 Jun;
91:129351.
PMID: 37270073
A property-focused optimization strategy was employed to modify the carboxylic acid head group of a class of EP4 agonists in order to minimize its absorption upon oral administration. The resulting...
4.
Parthasarathy U, Kuang Y, Thakur G, Hogan J, Wyche T, Norton Jr J, et al.
iScience
. 2023 Feb;
26(2):105948.
PMID: 36756375
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available. While singular...
5.
Mandal M, Xiao L, Pan W, Scapin G, Li G, Tang H, et al.
J Med Chem
. 2022 Dec;
65(24):16234-16251.
PMID: 36475645
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial...
6.
Parthasarathy U, Martinelli R, Vollmann E, Best K, Therien A
Biochem Pharmacol
. 2021 Nov;
195:114847.
PMID: 34801526
The host response to SARS-CoV-2, the virus that causes COVID-19, is highly heterogeneous, ranging from mild/asymptomatic to severe. The moderate to severe forms of COVID-19 often require hospitalization, are associated...
7.
Reens A, Cabral D, Liang X, Norton Jr J, Therien A, Hazuda D, et al.
Front Immunol
. 2021 May;
12:643255.
PMID: 34054810
Emerging evidence in clinical and preclinical studies indicates that success of immunotherapies can be impacted by the state of the microbiome. Understanding the role of the microbiome during immune-targeted interventions...
8.
Murgolo N, Therien A, Howell B, Klein D, Koeplinger K, Lieberman L, et al.
PLoS Pathog
. 2021 Feb;
17(2):e1009225.
PMID: 33596266
Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2...
9.
Gupta P, Zhang Z, Sugiman-Marangos S, Tam J, Raman S, Julien J, et al.
J Biol Chem
. 2017 Aug;
292(42):17290-17301.
PMID: 28842504
is a major nosocomial pathogen that produces two exotoxins, TcdA and TcdB, with TcdB thought to be the primary determinant in human disease. TcdA and TcdB are large, multidomain proteins,...
10.
Hernandez L, Kroh H, Hsieh E, Yang X, Beaumont M, Sheth P, et al.
J Mol Biol
. 2017 Feb;
429(7):1030-1044.
PMID: 28232034
The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced by the bacterial pathogen Clostridium difficile and are responsible for the pathology associated with C. difficile infection (CDI). The...