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Aleksandra Marchwicka

Explore the profile of Aleksandra Marchwicka including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 168
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Chemistry
Top 10 Co-Authors
Ewa Marcinkowska
Malgorzata Cebrat
Edyta Gendaszewska-Darmach
Geoffrey Brown
Hanna Baurska
Katarzyna M Blazewska
Urszula Nowak
Lukasz Sniezewski
Elzbieta Gocek
Agnieszka Laszkiewicz
Published In
Int J Mol Sci
J Steroid Biochem Mol Biol
Oncol Rep
PLoS One
Expert Opin Ther Pat
Affiliations
Soon will be listed here.
Recent Articles
1.
Vitamin D and immune system
Brown G, Marchwicka A, Marcinkowska E
Adv Food Nutr Res . 2024 May; 109:1-41. PMID: 38777411
The active metabolite of vitamin D 1,25(OH)D is well known for its role in regulating calcium-phosphate homeostasis of the human body. However, the immunomodulating activity of 1,25(OH)D has been known...
2.
Immuno-Stimulating Activity of 1,25-Dihydroxyvitamin D in Blood Cells from Five Healthy People and in Blasts from Five Patients with Leukemias and Pre-Leukemic States
Marchwicka A, Nowak K, Satyr A, Wolowiec D, Marcinkowska E
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047477
(1) Hematological malignancies are characterized by an immortalization, uncontrolled proliferation of blood cells and their differentiation block, followed by the loss of function. The primary goal in the treatment of...
3.
Overexpressed fibroblast growth factor receptors increase 1,25-dihydroxyvitamin D-dependent differentiation of acute myeloid leukemia cells
Marchwicka A, Nowak U, Grembowska A, Jakuszak A, Poreba P, Marcinkowska E
J Steroid Biochem Mol Biol . 2022 Aug; 224:106173. PMID: 36031072
Many malignancies are driven by mutations within the gene for fibroblast growth factor receptor 1 (FGFR1). Previously, we have shown that signal transduction from the FOP2-FGFR1 fusion protein in acute...
4.
Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization
Marchwicka A, Kaminska D, Monirialamdari M, Blazewska K, Gendaszewska-Darmach E
Int J Mol Sci . 2022 May; 23(10). PMID: 35628237
Protein prenylation is a post-translational modification controlling the localization, activity, and protein-protein interactions of small GTPases, including the Ras superfamily. This covalent attachment of either a farnesyl (15 carbon) or...
5.
Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase
Malolepsza J, Marchwicka A, Serwa R, Niinivehmas S, Pentikainen O, Gendaszewska-Darmach E, et al.
J Enzyme Inhib Med Chem . 2022 Mar; 37(1):940-951. PMID: 35354390
Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to...
6.
Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase
Kusy D, Marchwicka A, Malolepsza J, Justyna K, Gendaszewska-Darmach E, Blazewska K
Front Chem . 2021 Jan; 8:596162. PMID: 33490034
Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-]pyridin-3--2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature of the substituent in the C6 position of imidazo[1,2-]pyridine...
7.
Investigating the Role of Methylation in Silencing of Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts
Nowak U, Janik S, Marchwicka A, Laszkiewicz A, Jakuszak A, Cebrat M, et al.
Cells . 2020 Sep; 9(9). PMID: 32872475
(1) : Vitamin D receptor (VDR) is present in multiple types of blood cells, and its ligand, 1,25-dihydroxyvitamin D (1,25D), is important for the proper functioning of the immune system....
8.
Regulation of Expression of CEBP Genes by Variably Expressed Vitamin D Receptor and Retinoic Acid Receptor α in Human Acute Myeloid Leukemia Cell Lines
Marchwicka A, Marcinkowska E
Int J Mol Sci . 2018 Jul; 19(7). PMID: 29966306
All-trans-retinoic acid (ATRA) and 1α,25-dihydroxyvitamin D (1,25D) are potent inducers of differentiation of myeloid leukemia cells. During myeloid differentiation specific transcription factors are expressed at crucial developmental stages. However, precise...
9.
Synthesis and Biological Evaluation of Imidazole-Bearing α-Phosphonocarboxylates as Inhibitors of Rab Geranylgeranyl Transferase (RGGT)
Joachimiak L, Marchwicka A, Gendaszewska-Darmach E, Blazewska K
ChemMedChem . 2018 Mar; 13(8):842-851. PMID: 29498238
Rab geranylgeranyl transferase (RGGT) is an interesting therapeutic target, as it ensures proper functioning of Rab GTPases, a class of enzymes responsible for the regulation of vesicle trafficking. Relying on...
10.
Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation
Janik S, Nowak U, Laszkiewicz A, Satyr A, Majkowski M, Marchwicka A, et al.
Int J Mol Sci . 2017 Jun; 18(6). PMID: 28635660
Vitamin D receptor (VDR) is present in multiple blood cells, and the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is essential for the proper functioning of the immune system....