Aleksander Skardal
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Explore the profile of Aleksander Skardal including associated specialties, affiliations and a list of published articles.
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78
Citations
3575
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Recent Articles
1.
Hirway S, Nairon K, Skardal A, Weinberg S
Cell Mol Bioeng
. 2025 Feb;
17(6):573-596.
PMID: 39926379
Introduction: Colorectal cancer (CRC) is a major cause of cancer related deaths in the United States, with CRC metastasis to the liver being a common occurrence. The development of an...
2.
DePalma T, Hisey C, Hughes K, Fraas D, Tawfik M, Scharenberg J, et al.
Acta Biomater
. 2024 Oct;
189:155-167.
PMID: 39370091
Astrocytes play many essential roles in the central nervous system (CNS) and are altered significantly in disease. These reactive astrocytes contribute to neuroinflammation and disease progression in many pathologies, including...
3.
Nairon K, Nigam A, Khanal T, Rodriguez M, Rajan N, Anderson S, et al.
Biofabrication
. 2024 Oct;
17(1).
PMID: 39361514
Progressive metastasis is the primary cause of cancer-related deaths. It has been recognized that many cancers are characterized by long periods of stability followed by subsequent progression. Genes termed metastasis...
4.
5.
Skardal A, Sivakumar H, Rodriguez M, Popova L, Dedhia P
Endocr Relat Cancer
. 2024 Jan;
31(4).
PMID: 38289290
Graphical Abstract: Abstract: Endocrine tumors are a heterogeneous cluster of malignancies that originate from cells that can secrete hormones. Examples include, but are not limited to, thyroid cancer, adrenocortical carcinoma,...
6.
Lu Z, Miao X, Zhang C, Sun B, Skardal A, Atala A, et al.
Bioact Mater
. 2024 Jan;
34:1-16.
PMID: 38173844
Marrow niches in osteosarcoma (OS) are a specialized microenvironment that is essential for the maintenance and regulation of OS cells. However, existing animal xenograft models are plagued by variability, complexity,...
7.
Rist D, DePalma T, Stagner E, Tallman M, Venere M, Skardal A, et al.
ACS Sens
. 2023 Nov;
8(12):4636-4645.
PMID: 37988612
Integrins are cellular surface receptors responsible for the activation of many cellular pathways in cancer. These integrin proteins can be specifically targeted by small peptide sequences that offer the potential...
8.
Lu Z, Miao X, Song Q, Ding H, Rajan S, Skardal A, et al.
Theranostics
. 2023 Sep;
13(14):4905-4918.
PMID: 37771785
The liver metastasis accompanied with the loss of liver function is one of the most common complications in patients with triple-negative breast cancers (TNBC). Lineage reprogramming, as a technique direct...
9.
Dedhia P, Sivakumar H, Rodriguez M, Nairon K, Zent J, Zheng X, et al.
Sci Rep
. 2023 Sep;
13(1):15508.
PMID: 37726363
Adrenocortical carcinoma (ACC) has a poor prognosis, and no new drugs have been identified in decades. The absence of drug development can partly be attributed to a lack of preclinical...
10.
Mukherjee D, Chakraborty S, Bercz L, DAlesio L, Wedig J, Torok M, et al.
iScience
. 2023 Aug;
26(8):107408.
PMID: 37554459
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells...