Grand Challenges in Organoid and Organ-on-a-chip Technologies

Overview

Journal Front Bioeng Biotechnol

Date 2024 Mar 8

PMID 38456004

Authors

Aleksander Skardal

Affiliations

Soon will be listed here.

Citing Articles

Targeted Cancer Therapy-on-A-Chip.

Abed H, Radha R, Anjum S, Paul V, AlSawaftah N, Pitt W Adv Healthc Mater. 2024; 13(29):e2400833.

PMID: 39101627 PMC: 11582519. DOI: 10.1002/adhm.202400833.

References

Kang Y, Sodunke T, Lamontagne J, Cirillo J, Rajiv C, Bouchard M . Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms. Biotechnol Bioeng. 2015; 112(12):2571-82. DOI: 10.1002/bit.25659. View

Prince E, Cruickshank J, Ba-Alawi W, Hodgson K, Haight J, Tobin C . Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids. Nat Commun. 2022; 13(1):1466. PMC: 8933543. DOI: 10.1038/s41467-022-28788-6. View

Ronaldson-Bouchard K, Teles D, Yeager K, Tavakol D, Zhao Y, Chramiec A . A multi-organ chip with matured tissue niches linked by vascular flow. Nat Biomed Eng. 2022; 6(4):351-371. PMC: 9250010. DOI: 10.1038/s41551-022-00882-6. View

Skardal A, Shupe T, Atala A . Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discov Today. 2016; 21(9):1399-1411. PMC: 9039871. DOI: 10.1016/j.drudis.2016.07.003. View

Bauer S, Wennberg Huldt C, Kanebratt K, Durieux I, Gunne D, Andersson S . Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model. Sci Rep. 2017; 7(1):14620. PMC: 5668271. DOI: 10.1038/s41598-017-14815-w. View

Rajan S, Skardal A, Hall A . Multi-Domain Photopatterned 3D Tumor Constructs in a Micro-Physiological System for Analysis, Quantification, and Isolation of Infiltrating Cells. Adv Biosyst. 2020; 4(4):e1900273. PMC: 7323471. DOI: 10.1002/adbi.201900273. View

Ooft S, Weeber F, Dijkstra K, McLean C, Kaing S, van Werkhoven E . Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients. Sci Transl Med. 2019; 11(513). DOI: 10.1126/scitranslmed.aay2574. View

Skardal A, Murphy S, Devarasetty M, Mead I, Kang H, Seol Y . Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Sci Rep. 2017; 7(1):8837. PMC: 5562747. DOI: 10.1038/s41598-017-08879-x. View

Esch M, Ueno H, Applegate D, Shuler M . Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue. Lab Chip. 2016; 16(14):2719-29. DOI: 10.1039/c6lc00461j. View

10.

Sun W, Starly B, Daly A, Burdick J, Groll J, Skeldon G . The bioprinting roadmap. Biofabrication. 2020; 12(2):022002. DOI: 10.1088/1758-5090/ab5158. View

11.

Rajan S, Aleman J, Wan M, Zarandi N, Nzou G, Murphy S . Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform. Acta Biomater. 2020; 106:124-135. PMC: 11083435. DOI: 10.1016/j.actbio.2020.02.015. View

12.

Chen L, Yang Y, Ueno H, Esch M . Body-in-a-Cube: a microphysiological system for multi-tissue co-culture with near-physiological amounts of blood surrogate. Microphysiol Syst. 2021; 4. PMC: 8201523. DOI: 10.21037/mps-19-8. View

13.

Li H, Dai W, Xia X, Wang R, Zhao J, Han L . Modeling tumor development and metastasis using paired organoids derived from patients with colorectal cancer liver metastases. J Hematol Oncol. 2020; 13(1):119. PMC: 7650218. DOI: 10.1186/s13045-020-00957-4. View

14.

Maltman D, Przyborski S . Developments in three-dimensional cell culture technology aimed at improving the accuracy of in vitro analyses. Biochem Soc Trans. 2010; 38(4):1072-5. DOI: 10.1042/BST0381072. View

15.

Devarasetty M, Mazzocchi A, Skardal A . Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future. BioDrugs. 2018; 32(1):53-68. PMC: 7995645. DOI: 10.1007/s40259-017-0258-x. View

16.

Clevers H . Organoids: Avatars for Personalized Medicine. Keio J Med. 2019; 68(4):95. DOI: 10.2302/kjm.68-006-ABST. View

17.

Li J, Bardy J, Yap L, Chen A, Nurcombe V, Cool S . Impact of vitronectin concentration and surface properties on the stable propagation of human embryonic stem cells. Biointerphases. 2010; 5(3):FA132-42. DOI: 10.1116/1.3525804. View

18.

Aleman J, Skardal A . A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells. Biotechnol Bioeng. 2018; 116(4):936-944. PMC: 6399040. DOI: 10.1002/bit.26871. View

19.

Knowlton S, Tasoglu S . A Bioprinted Liver-on-a-Chip for Drug Screening Applications. Trends Biotechnol. 2016; 34(9):681-682. DOI: 10.1016/j.tibtech.2016.05.014. View

20.

Aleman J, George S, Herberg S, Devarasetty M, Porada C, Skardal A . Deconstructed Microfluidic Bone Marrow On-A-Chip to Study Normal and Malignant Hemopoietic Cell-Niche Interactions. Small. 2019; 15(43):e1902971. PMC: 8011350. DOI: 10.1002/smll.201902971. View