Julio Aleman
Overview
Explore the profile of Julio Aleman including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1970
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Recent Articles
1.
Aleman J, K R, Wiegand C, Schurdak M, Vernetti L, Gavlock D, et al.
Commun Biol
. 2024 Oct;
7(1):1317.
PMID: 39397070
Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM...
2.
Aleman J, Ravikumar K, Wiegand C, Schurdak M, Vernetti L, Gavlock D, et al.
bioRxiv
. 2024 May;
PMID: 38712135
Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in pancreatic islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of...
3.
Dip F, Aleman J, DeBoer E, Boni L, Bouvet M, Buchs N, et al.
Surgery
. 2022 Nov;
172(6S):S21-S28.
PMID: 36427926
Background: Published empirical data have increasingly suggested that using near-infrared fluorescence cholangiography during laparoscopic cholecystectomy markedly increases biliary anatomy visualization. The technology is rapidly evolving, and different equipment and doses...
4.
Aleman J, Kilic T, Mille L, Shin S, Zhang Y
Nat Protoc
. 2021 Apr;
16(5):2564-2593.
PMID: 33911259
Organs-on-chips have emerged as viable platforms for drug screening and personalized medicine. While a wide variety of human organ-on-a-chip models have been developed, rarely have there been reports on the...
5.
Trevisan B, Morsi A, Aleman J, Rodriguez M, Shields J, Meares D, et al.
Front Bioeng Biotechnol
. 2021 Mar;
9:639070.
PMID: 33732691
Microfluidic technology enables recapitulation of organ-level physiology to answer pertinent questions regarding biological systems that otherwise would remain unanswered. We have previously reported on the development of a novel product...
6.
Lu Z, Rajan S, Song Q, Zhao Y, Wan M, Aleman J, et al.
Biomaterials
. 2021 Jan;
269:120668.
PMID: 33461059
Generating microliver tissues to recapitulate hepatic function is of increasing importance in tissue engineering and drug screening. But the limited availability of primary hepatocytes and the marked loss of phenotype...
7.
Skardal A, Aleman J, Forsythe S, Rajan S, Murphy S, Devarasetty M, et al.
Biofabrication
. 2020 Feb;
12(2):025017.
PMID: 32101533
Current practices in drug development have led to therapeutic compounds being approved for widespread use in humans, only to be later withdrawn due to unanticipated toxicity. These occurrences are largely...
8.
Maloney E, Clark C, Sivakumar H, Yoo K, Aleman J, Rajan S, et al.
Micromachines (Basel)
. 2020 Feb;
11(2).
PMID: 32085455
The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new drug to market. Typically, drugs are tested on two-dimensional (2D) cell cultures and animal...
9.
Rajan S, Aleman J, Wan M, Zarandi N, Nzou G, Murphy S, et al.
Acta Biomater
. 2020 Feb;
106:124-135.
PMID: 32068138
Current drug development techniques are expensive and inefficient, partially due to the use of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity. To address this...
10.
Enck K, Rajan S, Aleman J, Castagno S, Long E, Khalil F, et al.
Ann Biomed Eng
. 2020 Jan;
48(3):1103-1111.
PMID: 31933001
To support the increasing translational use of transplanted cells, there is a need for high-throughput cell encapsulation technologies. Microfluidics is a particularly promising candidate technology to address this need, but...