Aleksander Skardal
Overview
Explore the profile of Aleksander Skardal including associated specialties, affiliations and a list of published articles.
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78
Citations
3575
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Recent Articles
11.
Dedhia P, Sivakumar H, Rodriguez M, Nairon K, Zent J, Zheng X, et al.
bioRxiv
. 2023 Feb;
PMID: 36747748
Adrenocortical carcinoma (ACC) has a poor prognosis, and no new drugs have been identified in decades. The absence of drug development can partly be attributed to a lack of preclinical...
12.
Che J, DePalma T, Sivakumar H, Mezache L, Tallman M, Venere M, et al.
Biotechnol Bioeng
. 2022 Dec;
120(4):1108-1119.
PMID: 36544242
Glioblastoma (GBM) is the most common form of brain cancer. Even with aggressive treatment, tumor recurrence is almost universal and patient prognosis is poor because many GBM cell subpopulations, especially...
13.
Clark C, Yoo K, Sivakumar H, Strumpf K, Laxton A, Tatter S, et al.
Biomed Mater
. 2022 Nov;
18(1).
PMID: 36332268
Organoids, and in particular patient-derived organoids, have emerged as crucial tools for cancer research. Our organoid platform, which has supported patient-derived tumor organoids (PTOs) from a variety of tumor types,...
14.
Forsythe S, Erali R, Laney P, Sivakumar H, Li W, Skardal A, et al.
Sci Rep
. 2022 Aug;
12(1):13865.
PMID: 35974123
Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous cancer, with incidence of less than 1/100,000, low survival rates and variable response to chemotherapy or immunotherapy. Herein we explore the...
15.
Nairon K, DePalma T, Zent J, Leight J, Skardal A
iScience
. 2022 Jul;
25(7):104645.
PMID: 35811850
Primary tumors secrete large quantities of cytokines and exosomes into the bloodstream, which are uptaken at downstream sites and induce a pro-fibrotic, pro-inflammatory premetastatic niche. Niche development is associated with...
16.
Forsythe S, Sivakumar H, Erali R, Wajih N, Li W, Shen P, et al.
Ann Surg Oncol
. 2022 Jul;
29(12):7354-7367.
PMID: 35780216
Introduction: Sarcoma clinical outcomes have been stagnant for decades due to heterogeneity of primaries, lack of comprehensive preclinical models, and rarity of disease. We hypothesized that engineering hydrogel-based sarcoma organoids...
17.
Forsythe S, Sivakumar H, Erali R, Skardal A, Votanopoulos K
Ann Surg Oncol
. 2022 Jul;
29(12):7368-7369.
PMID: 35778628
No abstract available.
18.
Baltazar T, Kajave N, Rodriguez M, Chakraborty S, Jiang B, Skardal A, et al.
J Biomed Mater Res B Appl Biomater
. 2022 May;
110(10):2323-2337.
PMID: 35532208
Xenogeneic sources of collagen type I remain a common choice for regenerative medicine applications due to ease of availability. Human and animal sources have some similarities, but small variations in...
19.
Kirk L, Waits C, Bashore A, Dosso B, Meyers A, Renaldo A, et al.
PLoS One
. 2022 Jan;
17(1):e0262173.
PMID: 35051193
The Modern Western Diet has been associated with the rise in metabolic and inflammatory diseases, including obesity, diabetes, and cardiovascular disease. This has been attributed, in part, to the increase...
20.
Mazzocchi A, Yoo K, Nairon K, Kirk L, Rahbar E, Soker S, et al.
Biomed Mater
. 2021 Dec;
17(2).
PMID: 34937006
Currentthree-dimensional (3D) models of liver tissue have been limited by the inability to study the effects of specific extracellular matrix (ECM) components on cell phenotypes. This is in part due...