Alejandro Pironti
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Explore the profile of Alejandro Pironti including associated specialties, affiliations and a list of published articles.
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41
Citations
491
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Recent Articles
11.
Savin A, Anderson E, Dyzenhaus S, Podkowik M, Shopsin B, Pironti A, et al.
Infect Immun
. 2024 Jan;
92(2):e0052623.
PMID: 38235972
is a gram-positive pathogen that poses a major health concern, in part due to its large array of virulence factors that allow infection and evasion of the immune system. One...
12.
Ilmain J, Perelman S, Panepinto M, Irnov I, Coudray N, Samhadaneh N, et al.
J Biol Chem
. 2023 Oct;
299(12):105321.
PMID: 37802313
Staphylococcus aureus (S. aureus) is a serious global pathogen that causes a diverse range of invasive diseases. S. aureus utilizes a family of pore-forming toxins, known as bi-component leukocidins, to...
13.
Jang K, Heaney T, London M, Ding Y, Putzel G, Yeung F, et al.
Cell Host Microbe
. 2023 Aug;
31(9):1450-1468.e8.
PMID: 37652008
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
14.
Zhu J, Abruzzo A, Wu C, Bee G, Pironti A, Putzel G, et al.
PLoS Pathog
. 2023 Aug;
19(8):e1011509.
PMID: 37540710
Among the many oral streptococci, Streptococcus pneumoniae (Spn) stands out for the capacity of encapsulated strains to cause invasive infection. Spread beyond upper airways, however, is a biological dead end...
15.
Azzouz D, Chen Z, Izmirly P, Chen L, Li Z, Zhang C, et al.
Ann Rheum Dis
. 2023 Jun;
82(10):1315-1327.
PMID: 37365013
Objective: Whereas genetic susceptibility for systemic lupus erythematosus (SLE) has been well explored, the triggers for clinical disease flares remain elusive. To investigate relationships between microbiota community resilience and disease...
16.
Limon G, Samhadaneh N, Pironti A, Darwin K
mBio
. 2023 Jun;
14(4):e0036323.
PMID: 37350636
is a major human pathogen and the causative agent of tuberculosis disease. is able to persist in the face of host-derived antimicrobial molecules nitric oxide (NO) and copper (Cu). However,...
17.
Podkowik M, Perault A, Putzel G, Pountain A, Kim J, DuMont A, et al.
bioRxiv
. 2023 Jun;
PMID: 37333372
The quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of HO, a crucial host defense against . We now report that...
18.
John A, Perault A, Giacometti S, Sommerfield A, DuMont A, Lacey K, et al.
mBio
. 2023 Feb;
14(2):e0259022.
PMID: 36779722
Nosocomial infections caused by multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) pathogens are on the rise. However, the virulence strategies employed by these pathogens remain elusive. Here, we study the interaction...
19.
Sargsian S, Chen Z, Lee S, Robertson A, Saes Thur R, Sproch J, et al.
Cell Rep
. 2022 Nov;
41(9):111725.
PMID: 36450245
Soil-transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia,...
20.
Bernard-Raichon L, Venzon M, Klein J, Axelrad J, Zhang C, Sullivan A, et al.
Nat Commun
. 2022 Nov;
13(1):5926.
PMID: 36319618
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis...